The National Science Foundation awarded a three-year $400,000 project grant to the University of Rochester under the Mathematical and Physical Sciences program (CFDA 47.049). The grant supports collaborative research between the University of Rochester, New Jersey Institute of Technology, and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The team will determine the structure of these systems with near-atomic...
Under this $200,000 Project Grant from the National Science Foundation Division of Chemistry's Mathematical and Physical Sciences program (CFDA 47.049), the New Jersey Institute of Technology will collaborate with the University of Rochester and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The collaborative team will determine the structure of these systems with near-atomic precision using cryo-electron...
This $115,114 federal Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences (CFDA 47.049) program supports research to develop and characterize novel biomaterials made from folded globular proteins. The project aims to: Experimentally characterize the mechanical response of the protein building blocks at the single-molecule level under varying force, tethering geometry, and solution conditions. Directly relate the observed domain unfolding of the...
Under a $530,000 National Science Foundation Project Grant awarded August 1, 2023 through the Mathematical and Physical Sciences program (CFDA 47.049), Professor Anatoly Kolomeisky of William Marsh Rice University and his research group will develop quantitative models and theoretical frameworks to understand the role of heterogeneity in chemical and biological processes. Through analytical models, numerical calculations, machine learning, and molecular dynamics simulations, the team will...
This $300,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) aims to enhance the design of fluorinated protein fibers and hydrogels for medical use. The key objectives are to: 1) generate coiled-coil fluorinated fibers for controlled drug encapsulation, 2) develop fluorinated coiled-coil hydrogels that can change with temperature, and 3) assess the potential of these fluorinated materials as imaging agents for 19F...
This $236,662 National Science Foundation award through the Mathematical and Physical Sciences program (CFDA 47.049) funds research at Emory University to develop novel biomimetic materials capable of simultaneously encoding both nucleic acid and protein information codes to control assembly and function. Specifically, the award supports exploration of "bilingual biopolymers" using peptide nucleic acid as a scaffold to direct structure based on both peptide and nucleic acid...
This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program provides $451,460 to Emory University to conduct collaborative research on the computational design of peptide-based filamentous nanomaterials. The project, led by researchers from Emory University and the University of Illinois Chicago, aims to develop a general scientific approach to computation-guided design of...
This $500,000 federal Project Grant awarded by the National Science Foundation (NSF) under the Mathematical and Physical Sciences program (CFDA 47.049) supports research at Northwestern University to develop de novo designed proteins as mechano-responsive junctions in protein-polymer networks. The key objectives are to: (i) synthesize and computationally simulate de novo designed proteins and their respective protein-polymer networks, and (ii) develop techniques for mechanical characterization...
This Project Grant award for $145,598, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports the development of peptide-based, stimuli-responsive biomaterials for wound healing and drug delivery applications. The principal investigator at Baylor University will design three classes of self-healing, antimicrobial hydrogels that change stiffness in response to changes in redox state and pH. This research aims to generate...
This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials. The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of...