Project Grant 2304853
- The National Science Foundation awarded a three-year $400,000 project grant to the University of Rochester under the Mathematical and Physical Sciences program (CFDA 47.049). The grant supports collaborative research between the University of Rochester, New Jersey Institute of Technology, and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The team will determine the structure of these systems with near-atomic...
- The University of Virginia, as prime grantee, was awarded a three-year project grant of $199,999 by the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. Working with sub-grantees the University of Rochester and New Jersey Institute of Technology, the University of Virginia will determine the near-atomic structure...
- This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials. The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of...
- This $200,000 Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports a collaborative research effort led by New York University (NYU) School of Medicine. The project aims to enhance the design of fluorinated protein fibers and hydrogels for medical applications. Key objectives include: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing temperature-responsive fluorinated hydrogels,...
- This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program provides $451,460 to Emory University to conduct collaborative research on the computational design of peptide-based filamentous nanomaterials. The project, led by researchers from Emory University and the University of Illinois Chicago, aims to develop a general scientific approach to computation-guided design of...
- The National Science Foundation (NSF), through its Division of Chemical, Bioengineering, Environmental, and Transport Systems (CBET), awarded a $451,093 Project Grant to the New Jersey Institute of Technology (NJIT) to investigate the interactions between flexible nanofilaments and biological cell membranes. The research aims to understand the mechanisms by which these nanofilaments adhere to and induce deformation in human and animal cells, leading to the organization and self-assembly of the...
- This Project Grant award from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) provides $300,000 to New York University (NYU) to enhance the design of fluorinated protein fibers and hydrogels for medical applications. The key objectives are: 1) generating coiled-coil fluorinated fibers for controlled drug delivery, 2) developing fluorinated coiled-coil hydrogels that change with temperature, and 3) assessing the potential of these materials as...
- This Project Grant award of $300,000 from the National Science Foundation (NSF) Integrative Activities program (CFDA 47.083) supports the development and experimental validation of computational tools for simulation-guided design of DNA nanostructures and molecular systems. The project aims to integrate high-level and low-level computational models to enable more powerful and user-friendly multiscale modeling frameworks for DNA nanotechnology. Key objectives include parameterizing coarse-grained...
- This $597,945 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports research by Tobias W. Giessen at the University of Michigan, Ann Arbor to investigate the structure and function of peptide-modifying enzyme filaments found in bacteria and archaea. The proposed work will generate new insights into the self-assembly and catalytic activity of these filamentous enzymes, which...
- This three-year, $455,159 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research into the self-assembly of collagen-like octadecamers based on the stem region of C1q and related defense collagens. Principal Investigator Jeffrey Hartgerink at William Marsh Rice University will study the hierarchical assembly of collagen mimetic peptides derived from collagen's branch and stem regions using solid phase peptide synthesis,...
Under this $200,000 Project Grant from the National Science Foundation Division of Chemistry's Mathematical and Physical Sciences program (CFDA 47.049), the New Jersey Institute of Technology will collaborate with the University of Rochester and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The collaborative team will determine the structure of these systems with near-atomic precision using cryo-electron microscopy and computer simulations. They will also work to rationally design rippled beta-sheet nanofibril systems and test computational predictions of novel self-assembled beta-sheet peptide materials experimentally. This research aims to provide insights into the molecular basis for peptide self-assembly relevant to understanding protein misfolding and designing new biomaterials. The three-year award period runs from August 1, 2023 through July 31, 2026.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $200.0k | 5/16/23 |