Project Grant 2435368
- This $100,000 National Science Foundation Technology, Innovation, and Partnerships grant funds the development of tunable porosity aerogel for wound care dressings at The University of Akron from July 1, 2022 to June 30, 2023. The project aims to create a novel bio-based aerogel dressing that could help heal patients with chronic wounds faster by requiring fewer dressing changes. Aerogels' high porosity, surface area and moisture balance properties may create an incubator-like wound healing...
- This National Science Foundation (NSF) Engineering Research Initiation (ERI) Project Grant, awarded by the NSF Division of Chemical, Bioengineering, Environmental, and Transport Systems, aims to develop a new type of bioadhesive using hydrophilic polydopamine (HPDA) to improve healing of inner meniscus tears. The project will synthesize and characterize HPDA, then incorporate it into hydrogel-based bioadhesives to be tested in vitro. The specific objectives are to understand the adhesion...
- This National Science Foundation (NSF) CAREER award of $152,007, granted under the Mathematical and Physical Sciences federal grant program (CFDA 47.049), aims to develop a simple and efficient method for creating structured hydrogels using liquid-liquid phase separation. The project, conducted by the University of New Hampshire, seeks to engineer hydrogels with customizable microstructures that vary in shape, size, and stiffness to better understand how material structure affects mechanical...
- This federal Project Grant award of $400,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by Baylor College of Medicine to develop and optimize bioengineered polymers with tunable properties to modulate inflammatory responses in the wound microenvironment. The goal is to enhance tissue repair and regeneration across different wound types, particularly in chronic wounds where...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop a hyperstable and bioactive FGF1-FGF2 dimer formulation for effective healing of diabetic skin wounds. The $435,226 award to the University of Arkansas will fund research activities across three key objectives: Designing a hyperstable and bioactive FGF1-FGF2 dimer and its variants, Developing injectable anionic...
- The National Science Foundation (NSF) awarded a $275,000 Project Grant under the NSF Technology, Innovation, and Partnerships (CFDA 47.084) program to Auxilium Health, Inc. for the development and validation of an aerogel-based biomaterial wound dressing. The proposed innovation aims to create a multi-layer wound dressing platform with integrated fluid management, biofilm prevention, and rapid infection detection capabilities to improve the management of acute wounds, chronic wounds, surgical...
- This $235,977 Project Grant awarded by the National Science Foundation (NSF) under the Integrative Activities program (CFDA 47.083) will support a collaboration between the University of Maine (UMaine) and the Molecular Foundry at Lawrence Berkeley National Laboratory to develop a new class of biomimetic hydrogel materials for tissue engineering and stem cell therapy applications. The key objectives are to: 1) synthesize a library of functionalized peptoid conjugates capable of forming...
- This Project Grant award of $117,562 from the National Science Foundation's (NSF) Mathematical and Physical Sciences program (CFDA 47.049) supports fundamental research to develop a new class of bioadhesive implants by Worcester Polytechnic Institute (WPI). The project aims to create a modular bioadhesive design integrating a liquid adhesive layer and a solid hydrogel layer, providing both strong, stable adhesion to target tissues and tissue-specific mechanical compliance. The research will...
- This $100,000 Project Grant from the National Science Foundation's Technology, Innovation, and Partnerships program will support the development of an advanced wound care technology at Florida International University. Specifically, the university will create a bandage-integrated platform that provides feedback-mediated wound therapy to enable personalized care. The conformable platform is designed to non-invasively monitor multiple wound biomarkers in spatial detail and then apply targeted...
- This three-year, $681,444 National Science Foundation project grant supports collaborative research to develop tumor-mimetic collagen hydrogels for testing the role of structural cues on cancer cell migration. The Division of Chemical, Bioengineering, Environmental, and Transport Systems awarded the funding under the Engineering program (CFDA 47.041), which aims to foster innovation and excellence in engineering research. The Rochester Institute of Technology will receive the award to create a...
CAREER: STIMULI-RESPONSIVE BIOMATERIALS FOR WOUND HEALING AND DRUG DELIVERY -NON-TECHNICAL ABSTRACT WOUND HEALING AND ARTHRITIS TREATMENT ARE TWO AREAS THAT PEOPLE CARE ABOUT. NEW CLASSES OF ?SMART? HYDROGELS THAT RESPOND TO ENVIRONMENT AND CHANGE THEIR STIFFNESS WILL BE DEVELOPED FOR REMOVABLE WOUND DRESSINGS AND ARTHRITIS TREATMENT. THIS WORK WILL IMPROVE HEALING OUTCOME FOR MILLIONS OF PATIENTS EACH YEAR. IN ADDITION TO PRACTICAL APPLICATIONS, THESE MATERIALS WILL PROVIDE TOOLS AND METHODS THAT COULD BE USED BY EVERYONE TO RATIONALLY DESIGN HYDROGEL MATERIALS AND WILL CONTRIBUTE TO DEVELOPMENT OF THE WIDER FIELDS OF DYNAMIC NANOMATERIALS, DRUG DELIVERY AND BIOSENSING. THE EDUCATIONAL COMPONENT INTEGRATES RESEARCH EFFORTS AND SEVERAL EDUCATION PROGRAMS IN BIOMATERIALS BY 1) DEVELOPING A RESEARCH TRAINING PROGRAM FOR HIGH SCHOOL STUDENTS FROM SYRACUSE CITY SCHOOL DISTRICT (SCSD); 2) PROVIDING RESEARCH TRAINING FOR UNDERGRADUATE STUDENTS THAT PARTICIPATE IN RESERVE OFFICER TRAINING CORPS (ROTC) AT SYRACUSE UNIVERSITY AND 3) DESIGNING AN OUTREACH MODEL OF BIOMATERIALS FOR THE MILTON J. RUBINSTEIN MUSEUM OF SCIENCE AND TECHNOLOGY (MOST) IN SYRACUSE. THROUGH THESE MULTI-PRONG OUTREACH PROGRAMS, STUDENTS ACROSS DIFFERENT AGE GROUPS WILL BE INCLUSIVELY ENGAGED WITH A PARTICULAR EMPHASIS ON TRAINING WOMEN, UNDERREPRESENTED MINORITIES, AND REFUGEES. EDUCATIONAL PROGRAMS WILL NOT ONLY PROVIDE A TRAINING GROUND FOR FUTURE BIOCHEMISTS BUT WILL ALSO GENERATE VALUABLE RESULTS TO ADVANCE THE RESEARCH FIELD. TECHNICAL ABSTRACT THE GOAL OF THIS PROPOSAL IS TO DESIGN PEPTIDE-BASED, SMART, STIMULI-RESPONSIVE BIOCOMPATIBLE ANTIMICROBIAL MATERIALS THAT CHANGE THEIR STIFFNESS IN RESPONSE TO CHANGES IN REDOX STATE AND PH. SYNERGISTIC COMBINATION OF MULTIPLE PROPERTIES IS CRITICALLY IMPORTANT BECAUSE SELF-HEALING IS ESSENTIAL FOR DELIVERY OF THE HYDROGEL VIA A SYRINGE, ANTIMICROBIAL PROPERTIES AND CYTOCOMPATIBILITY ARE CRITICAL FOR PRACTICAL APPLICATIONS, AND REDOX SWITCHING ALLOWS THE REMOVAL OF THE GEL UPON ADDITION OF A MILD REDUCTANT OR DRUG RELEASE IN RESPONSE TO REACTIVE OXYGEN SPECIES (ROS). TOWARD THIS GOAL, THREE CLASSES OF STIMULI-RESPONSIVE MATERIALS WITH SELF-HEALING PROPERTIES WILL BE DESIGNED: 1) REDOX-SENSITIVE PEPTIDE HYDROGELS; 2) PH-RESPONSIVE HYDROGEL TO DELIVER FIBROBLAST CELLS INTO WOUND BED; 3) HYDROGELS THAT RESPOND TO BOTH CHANGES IN PH AND ROS. THIS WORK WILL GENERATE HYDROGEL MATERIALS FOR WOUND CARE AND ARTHRITIS TREATMENT AND WILL PROVIDE TOOLS AND METHODS FOR RATIONAL DESIGN OF FUNCTIONAL MATERIALS. THIS AWARD REFLECTS NSF'S STATUTORY MISSION AND HAS BEEN DEEMED WORTHY OF SUPPORT THROUGH EVALUATION USING THE FOUNDATION'S INTELLECTUAL MERIT AND BROADER IMPACTS REVIEW CRITERIA.- SUBAWARDS ARE NOT PLANNED FOR THIS AWARD.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $99.4k | 6/17/25 | ||
| Not listed | $145.6k | 6/27/24 |