Under this $200,000 Project Grant from the National Science Foundation Division of Chemistry's Mathematical and Physical Sciences program (CFDA 47.049), the New Jersey Institute of Technology will collaborate with the University of Rochester and University of Virginia to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. The collaborative team will determine the structure of these systems with near-atomic precision using cryo-electron...
The University of Virginia, as prime grantee, was awarded a three-year project grant of $199,999 by the National Science Foundation Division of Chemistry under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to investigate the supramolecular assembly of beta-sheet nanofibrils composed of mirror-image peptides. Working with sub-grantees the University of Rochester and New Jersey Institute of Technology, the University of Virginia will determine the near-atomic structure...
This Project Grant award from the National Science Foundation's Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports a collaborative research effort led by Emory University and the University of Illinois Chicago to design and develop peptide-based filamentous nanomaterials. The $300,000 award, effective from August 1, 2024 to July 31, 2027, will leverage computational methods to systematically explore the energetics and structural designability of...
The National Science Foundation (NSF) awarded a $600,000 Project Grant under the Mathematical and Physical Sciences program (CFDA 47.049) to Dr. Jeffrey D. Hartgerink of Rice University. The grant aims to reveal the atomic structure of collagen, the most abundant protein in the human body, and explore the circumstances under which unique collagen superstructures can form. The research will leverage extensive solid-phase peptide synthesis to assess the ability of engineered collagen peptides to...
This three-year, $455,159 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research into the self-assembly of collagen-like octadecamers based on the stem region of C1q and related defense collagens. Principal Investigator Jeffrey Hartgerink at William Marsh Rice University will study the hierarchical assembly of collagen mimetic peptides derived from collagen's branch and stem regions using solid phase peptide synthesis,...
The National Science Foundation (NSF) has awarded a $250,000 Project Grant under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of California, Merced. The grant, titled "LEAPS-MPS: EXPANDING THE PEPTIDE ASSEMBLY LANDSCAPE USING MULTIVALENT PEPTIDE MACROCYCLES WITH DESIGNABLE INTERMOLECULAR INTERFACES", supports research led by Professor Merg and his students aimed at developing new approaches for designing and constructing peptide-based nanomaterials....
This Project Grant award from the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) Federal Grant Program provides $451,460 to Emory University to conduct collaborative research on the computational design of peptide-based filamentous nanomaterials. The project, led by researchers from Emory University and the University of Illinois Chicago, aims to develop a general scientific approach to computation-guided design of...
The National Science Foundation (NSF) awarded a Project Grant of $575,457 on August 1, 2024 under the Mathematical and Physical Sciences (CFDA 47.049) program to the University of Montana for a research project titled "Elucidating the Assembly of Higher-Order Anion Foldamers: The Influence of Charge, Sterics and the HBExB." The project, led by Dr. Orion Berryman and his research group, aims to explore new ways to control the shape and properties of extended molecules that can adopt...
The National Science Foundation awarded a $298,911 Project Grant to New York University under the Mathematical and Physical Sciences federal grant program (CFDA 47.049) to support collaborative research on water-responsive, shape-shifting supramolecular protein assemblies. Over a three-year period from August 2023 to July 2026, NYU will work with professors from New York University, CUNY Advanced Science Research Center, and CUNY City College to develop protein polymers that can respond to...
The National Science Foundation (NSF) Division of Materials Research awarded a $499,999 Project Grant to Arizona State University (ASU) under the Mathematical and Physical Sciences program (CFDA 47.049). The three-year grant project aims to: 1) create 3D DNA crystal scaffolds to host and determine the structure of RNA aptamers; 2) attach and immobilize functional proteins like enzymes within the crystal lattices to develop catalytic materials; and 3) develop sub-100 nm DNA nano-crystals to...