Project Grant 2141650
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) federal Project Grant award of $1,180,492 to the University of Pennsylvania will fund research to investigate how beneficial microbes affect the evolution of plant defense traits. The project aims to determine how genetic variation in microbial symbionts influences heritable variation in host plant defense characteristics, such as leaf hairs that protect against insect damage. Additionally, the project will train...
- The National Science Foundation Division of Environmental Biology awarded The Pennsylvania State University a $714,745 Project Grant under the Biological Sciences federal grant program (CFDA 47.074) on July 15, 2022. The grant will fund research from July 2022 through June 2025 to identify the ecological role of spillover outcome on the evolution of disease emergence. The researcher will characterize virus dynamics and pathogen evolution following exposure of Caenorhabditis nematode hosts to...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Project Grant award provides $270,000 to fund a Postdoctoral Research Fellowship in Biology for FY 2025 through May 31, 2028. The project aims to uncover how epigenetic modifications influence bacterial adaptation, particularly in response to antimicrobial compounds. The research will investigate the role of epigenetic modifications in bacterial adaptation to environmental changes, the underlying mechanisms, and possible...
- This National Science Foundation (NSF) Project Grant award, under the Biological Sciences program (CFDA 47.074), will provide $382,727 to The Pennsylvania State University (Penn State) from August 15, 2023 to July 31, 2026. The project will develop a comprehensive "gene annotation pipeline" toolbox to rapidly identify the functions of unknown genes, especially in non-model organisms. This will involve creating a library of microbial strains that can select for key metabolic reactions...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The project aims to develop new experimental methodology for nuclear magnetic resonance (NMR) spectroscopy to gain quantitative insights into these regulatory mechanisms. The research...
- This National Science Foundation Project Grant of $138,000 supports an NSF Postdoctoral Fellowship in Biology for fiscal year 2022 under the Biological Sciences program (CFDA 47.074). The fellowship funds research and training investigating the role of genomic preadaptation and physiological state in modulating bacterial invasion success. Specifically, the fellow will quantify invasion outcomes across diverse Pseudomonas aeruginosa strains isolated from different environments. The fellow will...
- This National Science Foundation (NSF) Biological Sciences (CFDA 47.074) project grant awarded to Baylor College of Medicine seeks to uncover the specific genes that confer antibiotic resistance in E. coli through a novel approach inspired by statistical physics. The $1,534,925 award spanning Aug 2024 to Jul 2027 will grow E. coli cultures and analyze the mutational ensemble using thermodynamic principles to predict the genes underlying antibiotic resistance. This technique aims to bridge...
- Federal Project Grant Award Summary The National Science Foundation (NSF) Division of Molecular and Cellular Biosciences awarded a $900,000 Project Grant to the University of Pennsylvania on September 15, 2025, with completion targeted for August 31, 2028. This collaborative research initiative, funded under the Biological Sciences program (CFDA 47.074), investigates the mechanism of transcription factor (TF) functional divergence through "differential usage of shared binding sites"...
- The National Science Foundation awarded a $138,000 Project Grant to support research activities from November 1, 2021 to October 31, 2023 under the Biological Sciences program (CFDA 47.074). The grant funding will enable the grantee to conduct research at the University of Pittsburgh aimed at furthering understanding of the evolution of gene regulatory networks through empirical and theoretical approaches. The Biological Sciences program seeks to advance the field and strengthen the national...
- Federal Project Grant Award Summary The University of Pennsylvania received a $702,401 Project Grant from the National Science Foundation's Division of Environmental Biology under the Biological Sciences program (CFDA 47.074), effective September 1, 2025 through August 31, 2029. This collaborative research initiative delivers scientific research outputs focused on understanding how rapid evolution shapes competitive interactions and species coexistence in orchard fly systems. The project...
This National Science Foundation Project Grant of $410,392 awarded on May 1, 2022 to The Pennsylvania State University supports collaborative research under the Biological Sciences federal grant program (CFDA 47.074) to understand xenobiotic adaptation through investigations of copy number alterations. The three-year project will discover novel aspects of xenobiotic resistance resulting from interactions between mutations and gene amplifications in the context of antibiotic resistance evolution induced by rifampin in E. coli. Researchers will mathematically model resistance evolution as a function of plasmid copy number using a stochastic process accounting for tunneling rates and community structures. Synthetic biology experiments are designed to parameterize models under development and explore specific parameter effects. The award also supports STEM graduate student training, undergraduate research opportunities, and development of K-12 educational games teaching science concepts like xenobiotic evolution.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $410.4k | 4/29/22 |