Project Grant 2142720

Award Date 2/1/22
Completion Date 1/31/25
Dollars Obligated $322K
Funding Federal Agency
Division of Emerging Frontiers
Awarding Federal Agency
Division of Environmental Biology
Federal Grant Program
47.074
Assistance Type
Project Grant
Place of Performance
New Haven, CT 06520, USA
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Specifically, the grant will further the biological sciences and understanding of major problems by funding three aims. Researchers will monitor the evolution of a plasmid-borne beta-lactam antibiotic resistance gene as it transfers between Escherichia coli, Salmonella enterica, and Klebsiella pneumoniae. They will also determine why certain mutations are favored during horizontal transfer and incorporate more realistic microbial community features into a computational model, testing it with horizontal transfer enabled or disabled. Overall, the project seeks to elucidate the role of horizontal genetic inheritance in bacterial community evolution and the development of antibiotic resistance.

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