This three-year, $321,668 Project Grant from the National Science Foundation's Division of Emerging Frontiers will fund research into the impact of horizontal gene transfer on genetic evolution in bacteria. Awarded to Yale University on February 1, 2022 and set to be completed by January 31, 2025, this grant supports work under the Biological Sciences program (CFDA 47.074). Specifically, the grant will further the biological sciences and understanding of major problems by funding three aims. Researchers will monitor the evolution of a plasmid-borne beta-lactam antibiotic resistance gene as it transfers between Escherichia coli, Salmonella enterica, and Klebsiella pneumoniae. They will also determine why certain mutations are favored during horizontal transfer and incorporate more realistic microbial community features into a computational model, testing it with horizontal transfer enabled or disabled. Overall, the project seeks to elucidate the role of horizontal genetic inheritance in bacterial community evolution and the development of antibiotic resistance.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $321.7k | 1/28/22 |