This $500,000 Project Grant from the National Science Foundation Division of Molecular and Cellular Biosciences, under the Biological Sciences federal grant program (CFDA 47.074), will support research to develop an end-to-end continuous manufacturing process for cell therapies using robotics and microfluidic technologies. The Georgia Tech Research Corporation will receive funding to create a more integrated workflow based on microfluidic device-enabled genetic engineering, cell expansion, and label-free cell purification techniques. These technologies will be applied to an induced pluripotent stem cell-derived retinal organoid manufacturing process. Under a subaward, researchers at The University of Iowa will work to demonstrate vector design for CRISPR/Cas9 gene correction, differentiation of iPSCs to retinal phenotypes, and generation of retinal organoids following cell separation using the new microfluidic and robotic methods. The goal is to establish a more continuous and automated production process that enables nimbler process control in compliance with cGMP standards for generating functional retinal cell grafts.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $500.0k | 8/9/21 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
AWD003432G1S | The University Of Iowa | Project Grant 2134701 | $354.0k | 12/21/22 |