This National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) Project Grant award is providing $600,120.00 to the Icahn School of Medicine at Mount Sinai to develop a groundbreaking microfluidic-based weighing scale instrument capable of measuring mass changes in live single cells with picogram resolution and millisecond temporal resolution. The instrument will utilize small pipettes to precisely attach to individual cells without the need for adhesion molecules, enabling continuous monitoring of cell mass changes during critical processes like cell division, metabolism, and migration. This transformative technology is expected to significantly advance biological research by providing unprecedented insight into cellular regulation of mass. The project also includes educational outreach programs to provide research and entrepreneurship experiences for underrepresented and economically disadvantaged students, promoting diversity in STEM fields. The award commences on August 1, 2024 and is scheduled for completion by July 31, 2028. No sub-awards are planned under this grant.
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