Project Grant 20246701842457
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $6,522,833 Project Grant to The Leland Stanford Junior University to conduct a mechanistic randomized clinical trial investigating the central and peripheral nervous system mechanisms of pain relief induced by peripheral nerve stimulation (PNS) for the treatment of refractory chronic neuropathic pain. The 3-year study, funded under the NIH HEAL Initiative's CFDA 93.279 Drug Abuse and Addiction Research Programs, aims...
- The National Center for Complementary and Integrative Health (NCCIH), part of the U.S. Department of Health and Human Services, awarded a $437,458 Project Grant under CFDA Program 93.213 "Research and Training in Complementary and Integrative Health" to the University of Illinois. The grant will fund a 2-year randomized crossover study exploring the effects of a Mediterranean diet on gut microbiome composition and chronic pain in 24 adults with sickle cell disease. The study aims to...
- The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $1,643,228 Cooperative Agreement grant under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to Worcester Polytechnic Institute (WPI) to develop an Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment (IMPACT). The key objectives of this 2-year IMPACT project are to: 1) Initiate a clinical trial of Mindfulness-Based Stress Reduction (MBSR) for chronic low back pain...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded Massachusetts General Hospital a $5.32 million Project Grant on August 15, 2025, to investigate the role of the gut microbiome in individual differences in lumbosacral radicular pain (LSRP) and treatment outcomes. The research will develop statistical and machine learning models to examine how gut microbiome composition and related metabolites mechanistically contribute to variability in pain...
- Summary The University of Washington received a $4.45M Cooperative Agreement from the National Institute of Neurological Disorders and Stroke under the Drug Use and Addiction Research Programs (CFDA 93.279) effective August 1, 2025 through July 31, 2028. The project adapts and implements a Nurse Care Management (NCM) model designed to address chronic pain in rural populations through an evidence-based, multi-component intervention. The NCM model integrates care coordination, cognitive behavioral...
- This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
- This $1,511,970 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports the development of selective GPR34 antagonists for the treatment of neuropathic pain. The award aims to identify CNS-active GPR34 hits that can be further developed into novel GPR34 antagonists as potential drug candidates for neuropathic pain. Key products and services include: 1) Synthesis and testing of novel...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded $407,113 to the University of California, Irvine on August 15, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to support development of novel KV7 channel modulators for pain therapy. This R21 exploratory research grant, which concludes July 31, 2027, will establish an empirical foundation for developing therapies targeting...
- Federal Cooperative Agreement Summary The National Institute of Neurological Disorders and Stroke awarded a $2.85 million Cooperative Agreement to the University of Michigan on September 19, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a Sequential Multiple Assignment Randomized Trial (SMART) study examining personalized treatment approaches for chronic low back pain. The project, titled "A SMART Design Study Using Patient-Based Algorithms for...
- This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) provides $376,310 to the University of North Carolina at Chapel Hill to develop the necessary documents and procedures to conduct a 16-week randomized controlled trial. The trial will test the efficacy and biochemical mechanisms of a dietary intervention involving increasing omega-3 fatty acids (EPA...
** AWARDS ISSUED PRIOR TO JANUARY 20, 2025, WERE FUNDED UNDER PREVIOUS ADMINISTRATIONS AND MAY NOT REFLECT THE PRIORITIES AND POLICIES OF THE CURRENT ADMINISTRATION.** NEUROPATHIC PAIN AFFECTS THE QUALITY OF LIFE OF MANY AMERICANS. NON-PHARMACOLOGICAL STRATEGIES SUCH AS BIOACTIVE COMPOUNDS IN FOODS ARE BEING EXPLORED AS THERAPEUTICS BUT CAN ALSO SERVE AS TOOLS TO BETTER UNDERSTAND PAIN MECHANISMS. WE PREVIOUSLY REPORTED GINGER REDUCED NEUROPATHIC PAIN AND FAVORED GUT MICROBIOME IN ANIMALS. THIS STUDY IS TO TEST HOW 2 MONTHS OF GINGER SUPPLEMENTATION WOULD AFFECT INDIVIDUALS WITH SCIATICA. WE PLAN TO RECRUIT DIRECT PERSON-TO-PERSON SONICATION IN CLINICS, HEALTH FAIRS, COMMUNITY EVENTS, FLYERS, NON-SOLICITED EMAIL SYSTEM, CAMPUS ANNOUNCEMENTS, CLINICAL RESEARCH INSTITUTE WEBSITE, LOCAL RADIO, NEWSPAPERS, SENIOR NEWSLETTERS, AND TV SCRIPTS. WE PLAN TO ENROLL APPROXIMATELY 200-250 PATIENTS TO OBTAIN 80-100 QUALIFIED SUBJECTS AT THE START OF THE STUDY. AFTER SCREENING, QUALIFIED PARTICIPANTS WILL BE RANDOMLY ASSIGNED TO A NO-GINGER GROUP OR GINGER GROUP. THIS STUDY WILL FOCUSE ON GUT FUNCATION (GUT MICROBIOTA COMPOSITION, FECAL METABOLITES, AND PLASMA MARKERS FOR LEAKY GUT) (PRIMAYR OUTCOME), BLOOD METABOLIES, AND BRAIN ACTIVITY (SECONDARY OUTCOME). IN ADDITION, THIS STUDY WILL MONITOR SAFETY AS WELL AS THE CHANGES IN DIETARY INTAKE, PHYSICAL ACTIVITY, AND OTC.ALL OUTCOMES WILL BE ASSESSED AT BASELINE AND AFTER 2 MONTHS OF INTERVENTION. DATA WILL BE ANALYZED STATISTICALLY.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $607.6k | 5/16/24 |