The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $376,310 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of North Carolina at Chapel Hill (UNC-CH). The grant will fund a 16-week randomized controlled trial to test the efficacy and biochemical mechanisms of a dietary intervention targeting omega-3 and omega-6 fatty acids as a treatment for chronic low back pain. The project aims to develop and prepare all necessary documents and procedures to conduct the full-scale clinical trial, including updating the dietary intervention, completing regulatory/operating plans, and establishing data management protocols. This planning grant is part of a broader effort to translate preclinical and clinical research on the role of oxylipins, lipid signaling molecules, in regulating pain pathways into new non-addictive treatment options for chronic pain conditions.
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