Project Grant RM1NS128956

Award Date 9/20/23
Completion Date 8/31/26
Dollars Obligated $6.5M
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded an $11.2 million project grant to the University of Pittsburgh to define the mechanisms of pain relief associated with dorsal root ganglion and spinal cord stimulation. This three-year grant will support research under the Drug Abuse and Addiction Research Programs (CFDA 93.279) to advance understanding of neuromodulatory devices for chronic pain treatment. The University will conduct preclinical...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $9,237,770 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University to conduct the "IMPETUS: Integrated Mechanisms, Phenotypes, and Translational Underpinnings of Chronic Pain After Surgery" research project. The goal is to gain integrated mechanistic insights into peripheral and central biological processes that contribute to chronic postsurgical pain...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Abuse and Addiction Research Programs (CFDA 93.279), provides $2,505,537 to The Leland Stanford Junior University to develop a focused ultrasound (FUS) device for noninvasive, peripheral nerve blockade to manage acute pain. The goal is to provide an alternative to opioids and current peripheral nerve block techniques, which have significant limitations in acute pain management. The...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $3,565,780 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to develop a groundbreaking high-frequency trans-spinal magnetic stimulation (HF-TSMS) system for the non-invasive treatment of neuropathic pain. The funded project aims to create an HF-TSMS tool that can target neural pathways involved in...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $638,718 project grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to The Feinstein Institutes For Medical Research to conduct research on "Selective, Epineural Stimulation of Peripheral Nerves with Interferential Electrical Fields". The primary objectives are to: 1) Test the hypothesis that interferential current stimulation can selectively activate specific...
This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279), is focused on developing novel methods for selectively stimulating nociceptors (pain receptors) and measuring the brain's nociceptive-specific response in both healthy individuals and those with the chronic pain condition fibromyalgia. The $2,314,276 award to Emory University will fund the creation of a new...
This $2,249,392 Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to validate senescent cells as a target for the treatment of chronic pain in aging. The project aims to rigorously characterize the role of senescent neurons and their senescence-associated secretory phenotype (SASP) in driving dorsal root ganglion hyperexcitability and persistent pain following...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $5,666,172 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to New York University (NYU) to conduct research on targeting Schwann cell dysfunction and repair signaling in chemotherapy-induced painful peripheral neuropathy (CIPPN). The research aims to study the role of the peroxisome proliferator activated receptor gamma (PPARG) and low-density lipoprotein receptor related protein 1 (LRP1)...
This federal Project Grant award of $231,000.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) will support research to determine whether electrical stimulation of distinct subregions within the human insula can differentially modulate sensory and higher-order, integrative aspects of pain processing. The research aims to provide proof-of-concept that multi-site insula...
The National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $970,052 Project Grant to Backstop Neural, Inc. on Aug 20, 2024. The goal of this Phase I SBIR project is to demonstrate the feasibility of a novel, thin and softening epidural stimulation lead to treat chronic arm and neck pain. The key products to be delivered include: 1) Design and fabrication of a 16-channel, 0.2 mm thick human-sized softening...

The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $6,522,833 Project Grant to The Leland Stanford Junior University to conduct a mechanistic randomized clinical trial investigating the central and peripheral nervous system mechanisms of pain relief induced by peripheral nerve stimulation (PNS) for the treatment of refractory chronic neuropathic pain. The 3-year study, funded under the NIH HEAL Initiative's CFDA 93.279 Drug Abuse and Addiction Research Programs, aims to characterize biopsychosocial predictors of PNS treatment response.

The project will enroll 134 patients with lower extremity chronic neuropathic pain due to peripheral nerve injury, randomizing them to conventional medical management or combined PNS and conventional treatment. Key activities include quantitative sensory testing, PET/MRI and PET/CT imaging with a novel sigma-1 receptor radiotracer, and remote outcome assessments over 1 year. The University of Kansas Medical Center Research Institute (KUMCRI) and University of Wisconsin-Madison are sub-awardees providing specialized expertise in study procedures and PET/MRI image analysis, respectively.

Generated 7/16/24, 7:08 AM