This federal Project Grant award of $1,511,970.00 from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to develop selective GPR34 antagonists for treating neuropathic pain. The award to Saint Louis University aims to identify CNS-active GPR34 antagonists as potential non-opioid-based therapeutics for neuropathic pain, which affects 15-20 million people in the U.S. The research involves synthesizing and evaluating GPR34 antagonist compounds, assessing their ability to reverse neuropathic pain behaviors in animal models, and elucidating the mechanisms by which GPR34 signaling contributes to neuropathic pain. Preliminary data suggests GPR34 antagonists can attenuate behavioral hypersensitivities in rodent models of neuropathic pain without observable side effects. The project period runs from September 19, 2024 to August 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $1.5m | 9/18/24 |