The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $603,502 Cooperative Agreement (UG3/UH3 grant type) to the University of North Carolina at Chapel Hill (UNC-CH) under the Oral Diseases and Disorders Research program (CFDA 93.121). The purpose of this 12-month award is to conduct a Phase 2B, proof-of-concept, randomized, placebo-controlled clinical trial to evaluate the safety and analgesic efficacy of a marine oil supplement containing omega-3 fatty acid derivatives in adults with chronic temporomandibular pain. The study aims to quantify safety, measure changes in pain intensity, and assess impacts on hyperalgesia, psychosocial distress, and sleep. The project will utilize advanced analytical methods to profile targeted bioactive lipid mediators and correlate biochemical changes with clinical outcomes. If successful, this research could lead to a novel therapeutic approach for chronic temporomandibular pain that resolves inflammation and reduces pain, sleep disturbance, and psychological distress.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $603.5k | 5/30/25 |