Project Grant K23DE034478

Award Date 5/1/25
Completion Date 4/30/29
Dollars Obligated $168K
Federal Grant Program
93.121
Assistance Type
Project Grant
Place of Performance
New Jersey, USA
Similar Awards
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $1,368,488 over approximately 5 years to investigate factors contributing to variability in the analgesic (pain relief) response to the non-opioid medication ibuprofen following third molar (wisdom tooth) extraction. The goal is to identify biomarkers that can predict which patients will require opioid...
This federal Project Grant award of $1,220,798 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to quantify nociceptive versus pain sensitivity in individuals with temporomandibular disorders (TMD). The project aims to develop a novel nociceptive-specific heating (NOSH) protocol to objectively measure nociceptor sensitivity and distinguish it from pain perception. The research will...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $589,725 to the University of Southern California (USC) to conduct research on mapping the molecular, cellular, and innervation changes in the temporomandibular joint (TMJ) that occur with osteoarthritis (OA). The key goals of this 5-year grant are to: 1) Create a comprehensive single-cell transcriptomic and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program provides $222,500 to The Children's Hospital of Philadelphia to conduct research on the pathogenic mechanisms of temporomandibular joint (TMJ) osteophyte formation. The project aims to test the hypothesis that a local decrease in heparan sulfate levels and increase in heparanase activity triggers osteophyte formation in...
This federal Project Grant award, valued at $800,000.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The award supports research efforts at Rutgers, The State University of New Jersey, to elucidate how the matrix metalloproteinase 13 (MMP13) enzyme regulates the dental pulp's reparative processes and immunological response in cases of acute pulpitis. The research aims to determine...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $587,428 Cooperative Agreement under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of California, Los Angeles (UCLA) on September 17, 2024. The objective of this 2-year award is to conduct comprehensive multi-omic analyses of temporomandibular joint (TMJ) disorders and associated comorbidities. Specifically, the project aims to identify distinct cell networks and molecular...
This $598,332 Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to understand the role of the truncated TRKB isoform, TRKBT1, in oral cancer pain. The key objectives are to investigate TRKBT1's influence on sensory neuron plasticity and pain behaviors, as well as its regulation of the tumor microenvironment in oral squamous cell carcinoma. The research...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $162,743 to New York University (NYU) from March 2025 to February 2030. The award aims to improve understanding of oral cancer pain mechanisms by: 1) developing and validating new methods to measure pressure and stretch sensitivity in oral cancer patients; 2) testing the impact of deleting the TRPV4 ion...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded Duke University a $2,372,115 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to identify and validate lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling as a novel target for treating temporomandibular disorder (TMD) pain. The project aims to determine the contribution of elevated LPA to TMD pain, dissect the role of LPAR in trigeminal ganglion sensory neurons, and examine whether...
This $238,668 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports research to diagnose and differentiate dental pain from stress using a wearable electrodermal activity (EDA) device. The University of Connecticut, as the primary awardee, will develop and validate a machine learning model to detect and distinguish EDA response patterns caused by stress versus pain during...

This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will fund a randomized controlled trial to evaluate the efficacy of a novel temporo-masseteric nerve block (TMNB) injection for reducing post-surgical pain and improving jaw function after impacted wisdom tooth extraction. The $168,228 award to Rutgers, The State University of New Jersey, will support the principal investigator, Dr. Subramanian, in conducting this pilot clinical trial and qualitative interviews to guide future study design. The goal is to develop a non-opioid pain management strategy that can complement analgesics and reduce reliance on opioids for this common dental procedure. The results from this 4-year project will inform the design of rigorous future trials to validate the TMNB intervention for managing post-operative pain and recovery.

Generated 4/8/25, 3:00 AM