This federal Cooperative Agreement award, funded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research grant program (CFDA 93.121), aims to conduct multi-omic investigations of temporomandibular joint (TMJ) disorders. The $587,428 award will support a two-phase project at the University of California, Los Angeles (UCLA) to: 1) develop protocols and infrastructure for data management, subject recruitment, and sample collection; and 2)...
This $222,500 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research at The Children's Hospital of Philadelphia (CHOP) to investigate the pathogenic mechanisms of temporomandibular joint (TMJ) osteophyte formation. The key objectives are to test whether conditional ablation of the gene EXT1, which is involved in heparan sulfate synthesis, causes osteophyte formation...
The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under its Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center (UNMC) division, to support research on targeting senescent cells for alleviating temporomandibular joint (TMJ) degeneration. The $350,000 grant, awarded on September 5, 2024, aims to define the role of p21-positive senescent cells in...
This Project Grant award, with an ID of R01DE032676, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The $2,372,115 award, spanning from July 2024 to June 2027, supports research to identify and validate the lysophosphatidic acid (LPA)/LPA receptor (LPAR) signaling pathway as a novel target for the treatment of temporomandibular disorder (TMD) pain. The primary research objectives are to: 1)...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), provides $1,831,197 to Emory University to conduct research on nociplastic pain mechanisms in temporomandibular disorders (TMD). The research project aims to separate nociceptive (stimulus-evoked) sensitivity from pain sensitivity using novel quantitative sensory testing methods, in order to better understand the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under CFDA Program 93.853 "Extramural Research Programs in the Neurosciences and Neurological Disorders", provides $620,278 to the University of Maryland, Baltimore to investigate the molecular basis for using sphingosine-1-phosphate receptor 1 (S1PR1) antagonists to treat the comorbid conditions of migraine and temporomandibular disorders (TMDs). The research aims to establish...
This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to characterize short cyclic phosphate-containing RNAs (CP-RNAs) and understand their biogenesis and biological functions. The $429,000 award to Thomas Jefferson University, doing business as Sidney Kimmel Medical College, will fund a genome-wide expression analysis of CP-RNAs across various cells and...
This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program, will evaluate the safety and analgesic efficacy of a marine oil supplement containing specialized pro-resolving mediators for the treatment of chronic temporomandibular disorder (TMD) pain in adults. The $603,502 award will fund a 12-month, triple-masked, randomized, placebo-controlled clinical trial that...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,013,625.00 to the University of Pittsburgh to conduct research on developing a safe and effective replacement for the temporomandibular joint (TMJ) disc. The proposed research focuses on evaluating the long-term functional remodeling of a porcine small intestine submucosa (SIS) scaffold into a neo-disc in a...
This Project Grant award, totaling $390,000.00, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program. The primary objective is to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). Key products and services to be delivered include: Optimizing a high-throughput, single-cell co-culture system...