This $390,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under its Oral Diseases and Disorders Research program (CFDA 93.121), supports research to leverage single-cell co-culture and gene expression profiling to identify tumor antigen-specific T cells in oral squamous cell carcinoma (OSCC). The key products and services to be delivered include: Optimizing a high-throughput, single-cell co-culture system to isolate individual tumor-killing T...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $109,548 Project Grant under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121) to the Regents of the University of Michigan. The grant supports a research project focused on investigating the role of myeloid cells in the evolution of precancerous oral lesions to head and neck squamous cell carcinoma (HNSCC). The project aims to develop a preclinical mouse model to study the transition from...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $226,500 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Medical University of South Carolina. The goal of this 2-year research project is to define how oral pathogens affect aging-associated immune responses and determine if inhibition of the CD38 enzyme can alleviate inflammatory bone loss and aging-associated immune responses induced by oral bacteria. The researchers will...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,676,355 project grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Pittsburgh. The grant, awarded on July 1, 2024, will support a 5-year research project to investigate how opioid usage suppresses anti-tumor immunity and limits the effectiveness of immune checkpoint inhibitor (ICI) therapy in head and neck squamous cell carcinoma (HNSCC). The research will use...
This federal Project Grant award, identified as R03DE033467, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The $339,000.00 award supports research conducted by New York University School of Medicine to investigate the role of autocrine cholinergic signaling in maintaining memory T cell responses in oral squamous cell carcinoma. The research project will take place from August 1, 2024, to...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $249,000 in funding to The Trustees of the University of Pennsylvania to conduct research aimed at understanding how human papillomavirus (HPV) disrupts the DNA damage response in HPV-positive head and neck squamous cell carcinoma (HNSCC). The goal is to identify vulnerabilities that can be targeted with combination...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $808,264 to The Medical University of South Carolina (MUSC) to conduct research aimed at uncovering the mechanisms by which a cell-penetrating peptide carrier can facilitate the intracellular delivery of small interfering RNA (siRNA) to target and treat oral and oropharyngeal cancers. The key focus is on...
This $234,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), supports research to determine the functional roles and mechanisms of the human microbiome in oral squamous cell carcinoma (OSCC) pathogenesis. The University of Colorado-Denver, through this grant, will 1) define OSCC-associated metagenomic and metabolomic signatures in treatment-naive OSCC cases and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $1,657,748 Project Grant (Grant No. R01DE034300) to Case Western Reserve University (CWRU) to conduct research on "Dual P300 and P53 Reactivation in HPV+ Head and Neck Cancer." This grant, awarded under the NIDCR's Oral Diseases and Disorders Research program (CFDA 93.121), aims to extensively determine the mechanisms of action of p53 and p300 reactivation in response to the lead compound OHM1 in...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $800,000 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Rutgers, The State University of New Jersey. The objective of this 1-year grant, with a start date of June 5, 2024, is to elucidate how the matrix metalloproteinase 13 (MMP13) protein regulates the dental pulp's reparative processes and the inflammatory response in acute pulpitis. The research project will leverage conditional...