This federal Project Grant award of $274,100 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant will fund research by New York University (NYU) to explore the role of the protease-activated receptor 2 (PAR2) in oral cancer pain signaling and develop targeted drug delivery systems. Specifically, the research aims to: 1) determine how oral cancer alters the trafficking and signaling of...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $168,228 to Rutgers, The State University of New Jersey to conduct a randomized, placebo-controlled pilot clinical trial evaluating the feasibility and potential efficacy of a novel local anesthetic injection technique called the Temporo-Masseteric Nerve Block (TMNB) for reducing post-surgical pain and improving jaw...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), will support research into nociplastic pain mechanisms in temporomandibular disorders (TMD). The $1,831,197 award, effective August 1, 2024 through July 31, 2025, will enable Emory University to employ quantitative sensory testing (QST) and a novel nociceptive-specific heating (NOSH) protocol to objectively...
This $2,854,699 five-year Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a collaborative research project to map the molecular, cellular, and innervation changes in the temporomandibular joint (TMJ) during osteoarthritis (OA) development. The project, led by researchers at the University of Southern California, aims to establish a comprehensive multi-modal...
The University of Pittsburgh received a $2,828,679 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The project aims to investigate the impact of opioids on anti-tumor immunity and immunotherapy response in head and neck squamous cell carcinoma (HNSCC). The research will use preclinical mouse models to study the functional role of opioid receptor signaling in CD8+ T cells and the...
This $161,762 Project Grant awarded on March 1, 2030 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will support research to define the role of the NG2/CSPG4 transmembrane proteoglycan in regulating the differentiation of osteochondral progenitor cells during endochondral ossification in mandibular fracture healing. The research plan utilizes a preclinical murine model of mandibular endochondral...
This Cooperative Agreement award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) will fund a Phase 2B clinical trial to evaluate the safety and analgesic efficacy of a marine oil dietary supplement in adults with chronic temporomandibular (TMD) pain. The $603,502 award to the University of North Carolina at Chapel Hill will support a randomized, placebo-controlled study examining the impact of the...
This $513,574 Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to decipher the cellular and genetic mechanisms underlying osteonecrosis of the jaw (ONJ). The research seeks to: (I) elucidate the pathways by which anti-resorptive medications like bisphosphonates can lead to ONJ, including identifying key cell types and molecular regulators, and (II) develop a genetic...
This Project Grant awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), will support research to diagnose and differentiate dental pain from stress using a wearable electrodermal activity (EDA) device. The $238,668 award to the University of Connecticut will fund the development of a machine learning model to detect and distinguish EDA signals related to pain versus stress, leveraging...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $319,624 in funding to the University of Florida for a 2-year research project from June 1, 2025 to May 31, 2027. The goal of the research is to develop statistical methods for assessing the marginal associations between dental caries and periodontal diseases, as well as their key determinants, using data from the...