Assistance Listing 93.848

The Department of Health and Human Services Public Health Service operates CFDA 93.848, a digestive disease research funding program that has not disbursed grants since April 2009 — over seventeen years ago. This program is inactive and should not be pursued.

The program funded biomedical research on gastrointestinal, hepatic, and metabolic diseases through predominantly Project Grants (94 percent of the portfolio) with a smaller share of Block Grants (6 percent). Recent awards covered molecular mechanisms in liver disease, pancreatic function, inflammatory bowel conditions, obesity treatment, and diagnostic technologies. Representative funded projects included copper transport mechanisms in Menkes disease and Wilson disease protein ($142,530), molecular characterization of folate uptake in pancreatic acinar cells ($35,711), mechanism of liver fibrosis and TGF-beta signaling ($108,688), and regulation of hepcidin and iron metabolism in liver disease ($123,928). The program also supported conference symposia and early-stage research fellowships, with Block Grant awards ranging from $12,000 for a trace element metabolism conference to over $1.2 million for multi-year investigative studies.

Funding came entirely from two Department of Health and Human Services entities: the Public Health Service accounted for 7,478 awards ($2.02 billion in federal dollars obligated), and HHS proper accounted for 479 awards ($119.2 million). Over its fifty-three-year history from 1976 to 2009, the program disbursed $2.14 billion across 7,957 total awards. Activity collapsed sharply after 2006: the program made 1,383 awards in 2005 and 1,374 in 2006, then dropped to 71 awards in 2007, 27 in 2008, and only 6 in 2009 before ceasing altogether.

No grant opportunities are currently open under this listing. The most recent award was made on April 1, 2009, and no solicitation activity has been posted in the intervening years.