Molecule Synthesis

The National Institutes of Health's Eunice Kennedy Shriver National Institute on Child Health and Human Development is seeking to procure highly specialized chemical compounds for research purposes through solicitation 75N94025Q00162. The procurement involves the synthesis of three specific molecular compounds: 20 grams each of T-1284-1(S) and T-1284-1(R), and 10 grams of T-1284-2(MR-5-19), all requiring strict purity specifications of over 98% with enantiomeric excesses greater than 99%. This represents a sole-source acquisition due to the proprietary technology required for synthesizing these unique research materials that do not occur naturally. Evaluation will be based on technical capability, price, and past performance, with technical capability and past performance weighted as significantly more important than cost. Quotations must be submitted by email to Kelly Robinson at Kelly.Robinson@nih.gov by August 29, 2025, at 12:00 PM, providing vendors with a 10-calendar day response window from the August 19, 2025 posting date.

This procurement is designated as a total small business set-aside under NAICS code 325998 with a size standard of 650 employees, and the solicitation specifically targets Creagen, Inc. of Woburn, Massachusetts as the intended contractor. The contract includes a performance period running from September 8, 2025, to September 7, 2026, with delivery scheduled for June 25, 2025, to Daniel Appella at a designated NIH location. The place of performance is listed as Woburn, Massachusetts, aligning with Creagen's location and specialized capabilities. The procurement represents a highly technical manufacturing requirement for research-grade chemical compounds that require proprietary synthesis technology. While specific award values are not disclosed in the available documentation, the specialized nature and purity requirements suggest this is a premium chemical synthesis contract supporting critical NIH research activities.