ATTACHMENT A.3_COSMOS Milestone and Payment Table.xlsx

This file is a milestone and payment table template for the ARPA-H Comprehensive Organ System Modeling in Outer Space (COSMOS) initiative. The document outlines mandatory deliverables and milestones organized by phase and task structure, with required submissions organized by month and quarter. Key Phase 1 deliverables include material transfer agreements with commercial service flight and hardware providers (Month 2, Q1); a commercialization plan describing how tissue aging rates in space (TARIS) exceeding tissue aging rates on Earth (TAROE) could be commercialized (Month 3, Q1); a collaboration plan and timeline with CSP-Technical teams (Month 5, Q2); and a Data Management and Sharing Plan revision if needed (Month 1, Q1). Additional Phase 1 requirements include quantification of tissue aging rates using microphysiological systems (MPSs) for target organs, development of licensable datasets combining terrestrial and Low Earth Orbit (LEO) twin data, commercial CSP hardware integration plans, and final TARIS:TAROE models.

By the end of Phase 1, teams must establish signed contractual partnerships and licensing agreements with at least one commercial pharmaceutical discovery or manufacturing partner with drugs applicable to the organ type showing the greatest TARIS:TAROE differential. Phase 2 deliverables include disease model development and scaling plans, credible and reproducible disease models using microgravity-leveraged MPS technology for novel drug screening, proof-of-concept high-throughput drug testing demonstrating identification of drugs that prevent or reverse age-related tissue dysfunction, Phase 2 commercial partnership plans, and TARIS-TAROE models tables. The document serves as a structured template for proposers to populate with specific task titles, milestone descriptions, quantitative metrics, and cost allocations across the defined start and end quarters for each phase.