The National Institute of General Medical Sciences (NIGMS) awarded a $358,862 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to GMJ Technologies, Inc., a minority-owned small business, to develop a microfluidic SDS depletion electrophoresis (SDE) interface. This interface will enable direct coupling of capillary electrophoresis with sodium dodecyl sulfate (CE-SDS) to mass spectrometry for improved characterization and quality control of monoclonal...
The National Institute of General Medical Sciences (NIGMS) awarded a $905,853 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Molecular Instruments, Inc. to develop innovative signal amplification technologies for automated, ultrasensitive, and multiplex imaging of RNA and proteins in biological samples. The 2-year project aims to engineer novel chromogenic and fluorescent signal amplification cascades based on hybridization chain reaction (HCR) to enable 4-plex RNA in...
The National Institute of General Medical Sciences (NIGMS) awarded a $400,530 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to the University of Virginia for the project "Designer Nanodiscs to Probe and Reprogram Membrane Biology." The research aims to advance the understanding of membrane protein-lipid interactions essential for human health, with a focus on interrogating how cell membranes regulate the structure, function, and dynamics of proteins involved...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $350,000 to Electronic Biosciences, Inc. to develop and demonstrate a novel enzyme-based, single-molecule protein sequencing system. The innovative platform aims to leverage enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high accuracy and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $2,297,901.00 to GMJ Technologies, Inc., a minority-owned small disadvantaged business, to develop a high-resolution native capillary zone electrophoresis system with inline UV and native mass spectrometry capabilities. This innovative analytical technology aims to improve the characterization and quality control...
The National Institute of General Medical Sciences (NIGMS) awarded a $300,518 Project Grant under CFDA Program 93.859 (Biomedical Research and Research Training) to E&E Bioclub LLC in Indianapolis, IN. The project aims to develop an all-in-one platform for intracellular overproduction of long, single-strand mRNA. This is intended to address challenges with current mRNA manufacturing methods, such as the cost and scalability constraints of in vitro transcription and the difficulty in...
The National Institute of General Medical Sciences (NIGMS) awarded a $349,816 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Narwhal Bio, Inc. in San Diego, CA. The grant supports the development of a prototype instrument, software, and consumable for non-invasive live-cell identification, tagging, and downstream characterization. This novel platform aims to enable researchers to study clinically relevant cell-cell interactions that drive diseases like...
The National Institute of General Medical Sciences (NIGMS) awarded a $218,622 Project Grant to Vitan-Biotech LLC on September 22, 2023 under the Biomedical Research and Research Training program (CFDA 93.859). The grant will fund the development of an integrated pipeline to rapidly discover and characterize selective, high-affinity nanobodies against defined G protein-coupled receptors (GPCRs) that are important for neurological disorders like schizophrenia, pain, Parkinson's, Alzheimer's, and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 Biomedical Research and Research Training provides $350,000 to Fluidispec LLC to develop a new microfluidic/nanofluidic sample preparation platform. The goal is to improve single-cell and low-input proteomics analysis by enabling efficient extraction of proteins from cells, removal of contaminants, and improved protein denaturation. This platform is expected to enhance...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $295,561 to Biosensing Instrument Inc. to develop a commercial prototype of their Plasmonic Scattering Microscopy (PSM) technology. The PSM system aims to enable high-throughput, label-free quantification of membrane protein binding kinetics on single cells in their native cellular microenvironment. This represents a...