Project Grant RM1NS128741

Award Date 9/22/22
Completion Date 8/31/25
Dollars Obligated $14M
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Charlestown, MA 02129, USA
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The Massachusetts General Hospital will investigate the mechanisms by which spinal cord stimulation reduces pain, with the goal of improving device design and patient selection. Researchers will apply specialized nerve conduction studies to detect changes in peripheral nerve excitability from SCS. Additional measurements will seek other potential mechanisms in the peripheral and central nervous systems, including microneurography to measure primary nociceptor modulation, PET-MRI to assess neuroinflammation changes, and plasma biomarkers to detect systemic inflammatory effects.

Researchers will conduct sensory phenotyping to identify mechanisms in specific patient subgroups and assess outcomes using pain and psychometric instruments. The study involves a multiple crossover design with SCS settings toggled between therapeutic and minimal in implanted patients. Sub-awardee Brigham and Women's Hospital will recruit at least one SCS patient per month and help coordinate their involvement across various study components at Massachusetts General and other hospitals.

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