This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $2,370,000 to Tufts University to develop innovative human pluripotent stem cell (HPSC) tools and region-specific models for studying pain circuitry. The project aims to create scalable methods for generating sensory neurons and glial subtypes, construct region-specific somatosensory organoids, and integrate HPSC-derived pain circuits into tissue-engineered models of women's health conditions like breast cancer metastasis and endometriosis. The goal is to deepen understanding of unique pain networks across the body and facilitate high-throughput screening of targeted analgesics. This 3-year award, beginning in September 2024, will leverage Tufts' expertise in stem cell biology, tissue engineering, and translational research to advance technologies with broad applications in neurological diseases, regenerative medicine, and beyond.
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