Project Grant RF1NS138437
- This $1,120,805 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders federal grant program (CFDA 93.853), will support research to investigate how prior SARS-CoV-2 infection may increase the risk of vascular contributions to cognitive impairment and dementia (VCID). The research aims to: Determine how prior SARS-CoV-2 infection influences blood-brain barrier...
- This $3,039,032 Project Grant award from the National Institute on Aging (under CFDA 93.866 - Aging Research) supports research on the potential links between SARS-CoV-2 infection and the initiation or acceleration of Alzheimer's disease and related dementias. The Baylor College of Medicine, a prestigious research institution in Texas, will conduct this work from August 2025 through July 2029. The key objectives are to investigate: (1) the relative contributions of genetic risk factors and...
- This Project Grant award for $2,398,590.00, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of brain microcirculation and capillary endothelial cell energetics in the development of vascular cognitive impairment and dementia (VCID) observed in Alzheimer's disease (AD) and AD-related dementias. The...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to investigate the role of Wnt/beta-catenin signaling in maintaining blood-brain barrier integrity and reversing neurological symptoms associated with post-acute sequelae of COVID-19 (NEUROPASC). The $801,329 award, with a project period from December 1, 2024 to...
- The National Institute on Aging (NIA) awarded a 3-year, $2,561,480 Project Grant (CFDA 93.866) to Brigham & Women's Hospital to study the post-acute sequelae of SARS-CoV-2 infection (PASC) and subsequent disease progression in individuals with mild cognitive impairment (MCI) or Alzheimer's disease (AD) and related dementias (ADRD). The project aims to: 1) understand the epidemiology of PASC in cognitively impaired individuals; 2) examine the impacts of COVID-19 and PASC on disease...
- The National Institute on Aging (NIA) awarded a $2,244,471 Project Grant under CFDA 93.866 (Aging Research) to Oregon Health & Science University (OHSU) to develop a first-in-class, CNS-penetrant small molecule agonist for G protein-coupled receptor 39 (GPR39) as a potential treatment for vascular cognitive impairment and dementia (VCID). The 3-year project from September 2023 to August 2026 will use in vitro and in vivo assays to identify lead compounds, determine their safety and...
- This federal Project Grant award for $369,823 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant supports research to investigate how SARS-CoV-2 infection and the viral S1 protein may induce cellular senescence in the brain and contribute to the development of Alzheimer's disease. Key research activities include studying the impact of the S1...
- The National Institute on Aging (NIA) has awarded a $640,906 project grant under CFDA 93.866 Aging Research to the University of Wisconsin-Madison to conduct research on "Elucidating Cerebrovascular Disease Pathways to Cognitive Decline with Vascular Neuroimaging." The 5-year project aims to utilize advanced neuroimaging techniques to understand the vascular contributions to cognitive impairment and dementia (VCID), and assess their relationship to Alzheimer's disease proteinopathy....
- This Project Grant award of $471,885.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) is focused on understanding the mechanisms underlying brain vascular endothelial cell (BVEC) disruption following vascular brain injury (VBI). The overarching goal is to determine how the glycosaminoglycan hyaluronan (HA) protects BVECs from ferroptosis, a form of programmed cell death, through a CD44-dependent mechanism. The specific aims are to: 1) test if high...
- This federal Project Grant award, issued by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $4,693,249 to the University of California, Los Angeles (UCLA) to conduct research on defining the molecular spectrum of white matter vascular lesions that drive vascular cognitive impairment and dementia (VCID). The project aims to develop a better understanding of...
This Project Grant award of $2,549,080.00, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the impact of SARS-CoV-2 infection on the cerebrovasculature as a risk factor for vascular contributions to cognitive impairment and dementia (VCID). The award, with a performance period from August 11, 2025 to July 31, 2029, will fund the University of Illinois to: The goals of this research are to identify mechanisms by which COVID-19 modifies the risk of VCID, a prevalent form of dementia, and explore potential therapeutic approaches to mitigate the impact of prior SARS-CoV-2 infection on the development of dementia.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.5m | 8/6/25 |