Project Grant RF1NS142171
Award Date 8/11/25
Completion Date 7/31/29
Dollars Obligated $3.2M
Funding Federal Agency
Awarding Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
New York, NY 10032, USA
Similar Awards
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,001,864 to Harvard University to investigate the subcellular mechanisms underlying the selective vulnerability of specific neuron subtypes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The researchers will quantitatively study the localization of RNA, proteins, and translational regulation in the synapses and soma of vulnerable corticospinal neurons (CSN) and...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to determine the functional significance of microglial FOXO3 in Alzheimer's disease (AD). The $475,377 award, effective from September 5, 2025 to August 31, 2027, will be used by the awardee, The Trustees of Columbia University in the City of New York, to conduct research on the role of the FOXO3 gene and associated IFN-I signaling pathways in microglial cells and their contribution to AD...
- This $3,360,074 federal Project Grant was awarded on September 15, 2025 by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866). The grant is funding research led by the University of Pennsylvania to develop short RNA therapeutics that can combat TDP-43 proteinopathy, a key pathological feature of several devastating neurodegenerative disorders including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. The research aims to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of the actin-binding protein profilin-1 (PFN1) in the pathogenesis of amyotrophic lateral sclerosis (ALS). The $3,323,710 award to the University of Massachusetts Medical School will fund two primary aims: 1) Interrogating the hypothesis that mutant PFN1 impairs autophagy and vesicular degradation through interactions with phosphatidylinositol 3-phosphate...
- This Project Grant award of $129,717 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the role of neutrophils in the pathology of amyotrophic lateral sclerosis (ALS). The research, conducted by the Regents of the University of Michigan, aims to identify neutrophil subpopulations and mechanisms associated with ALS progression and...
- This $461,900 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to study the mechanisms underlying TDP-43 dependent structural deficits in amyotrophic lateral sclerosis (ALS) muscles. The project, conducted by the Pennsylvania State University, aims to investigate how TDP-43, a protein involved in ALS and other neurodegenerative disorders, affects muscle function and structure. The research will utilize non-canonical amino acid...
- This Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the dysfunction of neuroimmune-related processes in animal models of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) associated with TAR DNA-binding protein 43 (TDP-43). The $251,250 award, effective from Apr 1, 2025 to Mar 31,...
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- This $146,922 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to investigate physiological pathways that modulate the regulation of the tau protein, which is associated with neurodegenerative diseases like Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). The research is being conducted by the Johns Hopkins University and aims to better understand how disruptions in the signaling pathway involving the enzyme GDE2 lead to...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...