Project Grant R21AG085675
- The National Institute on Aging (NIA) awarded a $442,357 Project Grant under the Aging Research program (CFDA 93.866) to the Research Foundation of the City University of New York (RFCUNY) on December 15, 2024. The grant aims to elucidate the molecular mechanisms that give rise to functionally neurodegenerative microglia, the brain's primary innate immune cells, which have been implicated as major determinants of Alzheimer's disease (AD) risk. The research will leverage novel mouse models and...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- This federal Project Grant award of $839,933 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate the role of N6-methyladenosine (m6A) RNA modifications in microglial dysfunction and Alzheimer's disease (AD) pathogenesis. The project aims to systematically map m6A modification landscapes in microglia isolated from human brain tissue and human induced pluripotent stem cell-derived microglial models. The researchers will also use CRISPR-based...
- This Project Grant award from the National Institute on Aging's Aging Research federal grant program (CFDA 93.866) provides $871,419 to the University of Washington to conduct research on the role of microglia, the brain's immune cells, in the pathogenesis of Alzheimer's disease. The research aims to characterize molecular profiles and spatial organization of microglia across the adult age spectrum, both with and without Alzheimer's disease, through single-nucleus RNA sequencing of over 5,000...
- This Project Grant award from the National Institute on Aging (NIA), CFDA 93.866 Aging Research program, provides $133,431 to the University of Oklahoma Health Sciences Center (OUHSC) to conduct research on the regulation of microglial function by major histocompatibility complex I (MHC-I) in aging and Alzheimer's disease. The overarching objective is to understand how increased expression of MHC-I and its receptors on microglia may contribute to age-related changes and neurodegeneration in...
- This $6,925,230 Project Grant award from the National Institutes of Health (NIH) National Institute on Aging (CFDA 93.866 - Aging Research) will support a research project at The Trustees of Columbia University in the City of New York to develop a "Multi-Organ Chart of Personalized Susceptibility to Alzheimer's Disease and Aging." The overarching goal is to use large-scale multi-omics, multi-organ biomedical data, advanced artificial intelligence/machine learning, and computational...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $749,030 to The Trustees of Columbia University in the City of New York to conduct research on the mechanisms connecting calcium signaling and autophagy defects in Alzheimer's disease (AD) neurons. The goal is to understand how dysregulation of neuronal calcium (Ca2+) signaling drives impaired autophagy, a key pathological process in AD. The research will evaluate the effects of...
- This $2,957,210 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the role of CD44-expressing astrocytes in Alzheimer's disease (AD) pathology. The award supports a 4-year research project undertaken by the Trustees of Columbia University in New York. The key objectives are to: 1) elucidate the signaling mechanisms by which CD44 alters astrocyte phenotype and function in vitro, and 2) investigate the impact of astrocytic CD44 on...
- The National Institute on Aging (NIA) awarded a $842,175 Project Grant under the Aging Research program (CFDA 93.866) to the J. David Gladstone Institutes in San Francisco, CA. The grant, awarded on December 15, 2024, will fund research to explore the role of the NOX2 enzyme in mediating Alzheimer's disease (AD) pathologies, including network hyperactivity, glucose hypometabolism, and accumulation of amyloid-beta and tau proteins. The research aims to assess the therapeutic efficacy of a novel...
- The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $1,684,689 project grant to Weill Medical College of Cornell University to study the role of microglial lysosomes in the degradation of amyloid-beta, a key pathological feature of Alzheimer's disease. The 3-year project aims to characterize the process of "digestive exophagy" used by microglia to limit the expansion of amyloid-beta plaques, as well as explore the effects of genetic...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to determine the functional significance of microglial FOXO3 in Alzheimer's disease (AD). The $475,377 award, effective from September 5, 2025 to August 31, 2027, will be used by the awardee, The Trustees of Columbia University in the City of New York, to conduct research on the role of the FOXO3 gene and associated IFN-I signaling pathways in microglial cells and their contribution to AD pathobiology. The research seeks to advance scientific understanding of the biological mechanisms underlying AD, with the goal of identifying potential therapeutic targets. This grant is part of the National Institute on Aging's broader mission to support biomedical and behavioral research to better understand the aging process and age-related diseases, particularly Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $475.4k | 9/5/25 |