This federal Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports comprehensive research into the vascular and neurological pathways linking atherosclerosis and Alzheimer's disease. The $4,815,513 grant will fund investigations into the structural, molecular, and functional aspects of the brain's microvasculature in mouse models of Alzheimer's amyloidosis, with a focus on evaluating the secretome of key vascular cell types as potential biomarkers. The project also aims to assess whether correcting hyperlipidemia, either pharmacologically or through dietary interventions, can restore the observed vascular alterations and correlate with changes in Alzheimer's disease severity. Additionally, the researchers plan to develop an integrated computational network to further elucidate the relationships between vascular health and Alzheimer's pathology, with the goal of informing future targeted interventions and therapeutic strategies. The grant, awarded to Northwestern University, is scheduled to run from September 18, 2024, to August 31, 2027.
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