This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $444,125 in funding to Duke University to explore the role of the LRRC55 regulatory protein in pain pathways. The key objectives are to: 1) delineate LRRC55's function in chronic pain behaviors using genetically-modified mice, 2) quantify changes in LRRC55 expression in dorsal root ganglion and spinal cord neurons...
The University of Utah was awarded a $349,335 Project Grant from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant, titled "University of Utah Program to Provide Pain Research Knowledge (UP3RK)", aims to prepare an interdisciplinary, diverse pool of well-trained clinical pain research scientists to address the nation's biomedical, behavioral, and clinical pain research needs. Specifically, the...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $441,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Duquesne University of the Holy Spirit. The purpose of this 3-year grant, beginning September 2023, is to utilize laboratory data and computational 3-D modeling to analyze the role of the central amygdala in neuropathic pain. Specifically, the project aims to build a proof-of-concept 3-D...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $391,830 to support research aimed at understanding how the dorsal column nuclei in the brainstem process tactile information and contribute to persistent pain. The research involves employing a combination of techniques, including viral tracing, optogenetics, and...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $838,750 to the University of Florida to conduct research on targeting GTP cyclohydrolase 1 (GTPCH1) for treating chronic orofacial pain. The study aims to investigate the role of GTPCH1 in an orofacial neuropathic pain model and its effects on pain-related brain regions and reward pathways. Specifically, the researchers...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $446,875.00 to generate and characterize a new NTRK3-FLPO mouse line. This transgenic mouse model will allow researchers to genetically label and manipulate mouse A-beta nociceptors, an important population of primary sensory neurons involved in mechanical pain...
The National Institute on Drug Abuse awarded a $708,397 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Research Foundation For The State University Of New York, doing business as Stony Brook University. The grant, titled "The Spinal Cell Atlas of Opioid-Targeted Inflammasomes in the HIV Pain Model: Mechanism and Pathogenic Role," aims to investigate the role of inflammasomes in the development of opioid-induced hyperalgesia, a heightened pain...
This $6,154,752 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), supports a 3-year clinical study to understand the interplay between menstrual pain (dysmenorrhea) and the development of chronic pelvic pain (CPP) conditions. The primary objectives are to determine if optimized anti-inflammatory (NSAID) treatment for menstrual pain can reduce the future risk of CPP, and to...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $129,113 to Seattle Children's Hospital to support a 9-week Summer Program to Advance Research and Equity in Pain and Neurological Health (SPARQ). The program aims to provide an immersive and rigorous mentored research experience in basic science, mechanistic, and...
This federal Project Grant award, funded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to identify the circuit basis for neuropathic pain in the parabrachial nucleus (PBN). The $124,713 award to Beth Israel Deaconess Medical Center, Inc. (Bidmc) aims to elucidate how different pain-related stimuli are integrated in the PBN, determine if specific...
The University of Rhode Island (URI) Research Office is receiving a $2,727,001 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Drug Abuse and Addiction Research Programs (CFDA 93.279). The grant will fund research to validate a rabbit model of cerebral palsy-induced pain. Key components include:
Determining the face validity of the rabbit hypoxia-ischemia model to assess musculoskeletal, nociplastic, and neuropathic pain phenotypes consistent with cerebral palsy through anatomical, physiological, and behavioral testing. Validating that sensory and behavioral measures in the rabbit model are reflective of the multifaceted pain experienced by people with cerebral palsy. Assessing the reproducibility and reliability of the rabbit model for pain research through training protocols and inter-experimenter reliability assessments.
The overall goal is to establish the rabbit hypoxia-ischemia model as a robust, translational platform for studying the neurobiology and treatment of chronic pain associated with cerebral palsy. The research is planned to be conducted from September 2023 through August 2026.