This Project Grant award of $597,999.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research focused on understanding the neuronal populations and central sensitization mechanisms underlying mechanical allodynia, a debilitating condition where normally innocuous touch or movement becomes painful after an injury. The key objectives of this 5-year...
This federal Project Grant award, valued at $764,659.00 and awarded by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research to investigate the role of neurovascular interactions in neuropathic spontaneous pain. The principal investigators at the University of Cincinnati will characterize how local vascular movement triggers neuropathic spontaneous pain,...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $242,310 to support research investigating the neural mechanisms underlying flexible escape behaviors in response to painful stimuli. The primary awardee, The Trustees of Columbia University in the City of New York, will utilize Drosophila larvae as a model organism to 1)...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), part of the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, provides $1,525,066 to study the functional connectivity of corticothalamic networks and their role in chronic pain. The 5-year project, with a start date of June 15, 2024, aims to elucidate the mechanisms by which sensory, cognitive, and affective information are integrated...
This $246,750.00 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of the mesocortical glutamatergic pathway in the development and maintenance of chronic neuropathic pain. The research, conducted by The Trustees of Columbia University in the City of New York, will combine in vivo calcium...
The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $441,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Duquesne University of the Holy Spirit. The purpose of this 3-year grant, beginning September 2023, is to utilize laboratory data and computational 3-D modeling to analyze the role of the central amygdala in neuropathic pain. Specifically, the project aims to build a proof-of-concept 3-D...
This $130,584 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) supports research on the negative regulatory mechanism of mechanically activated Piezo2 channels by the protein TMEM120A/TACAN. The research aims to investigate how TMEM120A, initially proposed as a mechanosensitive ion channel, actually functions as a lipid modifying enzyme that...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $444,125 to Duke University to conduct research exploring the role of the LRRC55 regulatory protein in pain mechanisms. The research aims to: 1) delineate LRRC55's function in chronic pain behaviors using LRRC55-deficient mice; 2) quantify changes in LRRC55 expression in dorsal root ganglion and spinal cord neurons...
This federal Project Grant award, totaling $279,548.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund research to thoroughly characterize unique sodium currents biophysics in human dorsal root ganglia (DRG) neurons at the University of Texas at Dallas. The research aims to identify novel therapeutic targets and inform the...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,314,276 to Emory University to develop and test novel methods for assessing nociceptive (pain-sensing) sensitivity and brain activity in both healthy individuals and those with fibromyalgia, a chronic pain condition. The key products and services to be delivered include: 1) Establishing a technique to...