Project Grant K99NS133476

Award Date 7/15/24
Completion Date 6/30/26
Dollars Obligated $392K
Federal Grant Program
93.853
Assistance Type
Project Grant
Place of Performance
Piscataway, NJ 08854, USA
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The funding will support research on the role of the dorsal column nuclei (DCN) in the brainstem and its distinct pathways to the thalamus and periaqueductal gray in mediating touch-evoked pain and persistent pain behaviors. The project aims to use advanced techniques like optogenetics, in-vivo calcium imaging, and machine-vision behavioral analysis to elucidate how disruption of the balance between these DCN pathways following injury can lead to touch stimuli engaging "pain" pathways. The results are expected to provide fundamental insights into how the DCN encodes tactile information and the neural circuits that promote touch-evoked pain in persistent pain states.

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