This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $444,125 in funding to Duke University to explore the role of the LRRC55 regulatory protein in pain pathways. The key objectives are to: 1) delineate LRRC55's function in chronic pain behaviors using genetically-modified mice, 2) quantify changes in LRRC55 expression in dorsal root ganglion and spinal cord neurons following chronic pain, and 3) test whether knockdown of LRRC55 can suppress chronic pain. This high-risk, high-reward research aims to identify LRRC55 as a novel, cell-type specific target for developing non-opioid based pain treatments, addressing the urgent need for alternatives to opioid analgesics. The award period runs from Sep 19, 2024 through Aug 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $444.1k | 9/19/24 |