This Project Grant from the National Institutes of Health's National Institute on Aging will fund research totaling $4,188,512 to the University of California, Davis from September 2022 through August 2025. The grant is part of the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research on aging processes and diseases affecting older populations. Specifically, the University of California, Davis will investigate the hypothesis that ultrafine particulate...
The National Institutes of Health National Institute on Aging awarded a $4.3 million project grant to the University of California Irvine to fund research on the neurotoxicity of particulate matter and its interaction with APOE in neurodegeneration from September 2022 through August 2025. The grant supports research to comprehensively evaluate the neurotoxicity of ambient particulate matter and its environmental risk in a novel mouse model of late-onset Alzheimer's disease. Researchers will also...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,278,304 to investigate the impact of fine particulate matter (PM2.5) exposure on the risk of developing Alzheimer's disease and related dementias (AD/ADRD). The primary awardee, Emory University, will characterize individual exposures to PM2.5 components, elucidate biological perturbations in brain, cerebrospinal fluid, and blood related to these toxicants, and determine the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,329,825.00 to Emory University to investigate the relationship between air pollution exposure, blood/brain metabolic changes, and the development of Alzheimer's disease and related dementias. The project aims to identify the specific air pollutant components that are most neurotoxic, explore the role of other common air pollutants, and elucidate the biological mechanisms underlying the link...
This federal Project Grant award of $1,625,947 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to investigate the link between air pollution-derived iron exposure, poverty-related stress, and Alzheimer's disease risk. The key objectives of the research project are to: 1) evaluate whether exposure to ambient and subway-level concentrations of...
This $1,827,512 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the Scripps Research Institute to study the molecular mechanisms by which environmental exposures, such as air pollution, interact with genetic risk factors to contribute to the pathogenesis of Alzheimer's disease (AD) and related dementias (ADRD). The project will utilize human-induced pluripotent stem cell (hiPSC)-derived 2D cultures and 3D cerebral organoids, as...
The National Institute on Aging (NIA) awarded a Cooperative Agreement totaling $4,422,126.00 to the Regents of the University of Michigan to conduct research under CFDA 93.866 - Aging Research. The project, titled "The Impact of Metals and Polygenic Risk on Multiomics, Brain Aging, and ADRD Outcomes," aims to comprehensively characterize how genetic risk interacts with exposure to toxic metals, including lead, cadmium, and arsenic, to cause molecular, behavioral, and pathological...
This three-year, $4.84 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at The Johns Hopkins University to investigate the neurological effects and cumulative risk of neurodegenerative disease from exposure to metal mixtures. Specifically, the researchers will examine the biological mechanisms by which exposure to mixtures of lead, arsenic, cadmium, and chromium during adulthood and early development cause...
The University of New Mexico Health Sciences Center was awarded a $3,925,264 Cooperative Agreement by the National Institute on Aging (CFDA 93.866 - Aging Research) to investigate the link between environmental exposures like microplastics, heavy metals, and wildfire smoke, and the incidence and progression of Alzheimer's disease and related dementias (ADRDs). The project, titled "PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and Dementia", will use...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) seeks to examine the role of the "exposome" as a risk factor for Alzheimer's disease (AD) among non-Hispanic whites, African Americans, and Mexican Americans. The $1,205,827 project, awarded on August 1, 2024, will utilize blood samples from 3,000 participants in the ongoing Health & Aging Brain Study - Health Disparities Study. The goal is to identify environmental exposures that may...