Project Grant RF1NS130659

Award Date 9/20/22
Completion Date 8/31/25
Dollars Obligated $4.2M
Funding Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Davis, CA, USA
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This Project Grant from the National Institutes of Health's National Institute on Aging will fund research totaling $4,188,512 to the University of California, Davis from September 2022 through August 2025. The grant is part of the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research on aging processes and diseases affecting older populations.

Specifically, the University of California, Davis will investigate the hypothesis that ultrafine particulate matter (PM) enters the brains of individuals exposed to air pollution and increases their risk of cognitive decline and Alzheimer's disease or Alzheimer's disease-related dementias. Researchers will analyze brain tissue from rats exposed to traffic-related air pollution to identify the source of ultrafine PM and its relationship to Alzheimer's pathology. They will also examine human data to determine if ultrafine PM exposure is associated with cognitive impairment, Alzheimer's diagnoses, or accelerated cognitive decline in older adults. Exploratory studies of brain samples from deceased human subjects aim to relate ultrafine PM deposits to Alzheimer's pathology as well. Results seek to establish the biological plausibility of air pollution's role in Alzheimer's occurrence and progression.

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