This Project Grant from the National Institutes of Health's National Institute on Aging will fund research totaling $4,188,512 to the University of California, Davis from September 2022 through August 2025. The grant is part of the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research on aging processes and diseases affecting older populations. Specifically, the University of California, Davis will investigate the hypothesis that ultrafine particulate...
The National Institute on Aging (NIA) awarded a $2,329,825 Project Grant (CFDA 93.866 - Aging Research) to Emory University to investigate the effects of air pollution on Alzheimer's disease and related dementias. The research aims to identify the specific components of fine particulate matter (PM2.5) and other air pollutants that are most neurotoxic, as well as understand the biological pathways linking air pollution exposure to brain health and cognitive decline. The project will leverage...
The National Institute on Aging (NIA) awarded a $2,151,314 Project Grant to the University of Missouri System under the Aging Research program (CFDA 93.866) to conduct research on the effects of fine particulate matter (PM) exposure on small cerebrovascular inflammation and cognitive dysfunction. The 3-year project aims to investigate how PM exposure induces sex-specific inflammatory responses mediated by TNF-alpha in males and IL-6 in females, leading to cognitive impairment. The research...
This Cooperative Agreement, awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), provides $2,278,304 in funding to Emory University to investigate the impact of fine particulate matter (PM2.5) air pollution exposure on the risk and underlying biological mechanisms of Alzheimer's disease and related dementias (AD/ADRD). The project, titled "IMPACT-ADRD: Investigating the Multi-Omics Perturbations Associated with Complex...
This federal Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,827,512 to the Scripps Research Institute to study the role of aberrant protein S-nitrosylation in mediating gene-environment interactions that contribute to the development of Alzheimer's disease (AD) and AD-related dementias (ADRD). The key objectives are to: 1) Determine the effects of air pollution exposure, specifically fine particulate matter and nitric oxide species, on...
The National Institute on Aging (NIA) awarded a $2,288,327 Project Grant (CFDA 93.866 - Aging Research) to the University of California, San Diego (UCSD) on August 15, 2024. The grant funding will support research to investigate the early determinants and pathogenesis of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patient samples. The research teams will utilize patient-derived induced neurons to study how polygenic risk factors and...
This three-year, $4.84 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at The Johns Hopkins University to investigate the neurological effects and cumulative risk of neurodegenerative disease from exposure to metal mixtures. Specifically, the researchers will examine the biological mechanisms by which exposure to mixtures of lead, arsenic, cadmium, and chromium during adulthood and early development cause...
The University of California Irvine will receive $4,522,968 over three years from the National Institutes of Health National Institute on Aging under the Aging Research grant program (CFDA 93.866) to investigate the temporal, spatial and cellular dynamics of amyloid plaque deposition in Alzheimer's disease. The research will utilize cutting-edge biorthogonal non-canonical amino acid tagging technology and cell-specific Cre driver mouse lines to label the proteomes of specific cell types and...
This $4,260,300 project grant from the National Institutes of Health's National Institute on Aging will fund research under the Aging Research program (CFDA 93.866) to investigate the association between in utero environmental exposures and life-course cognition and prodromal Alzheimer's disease in midlife. The Public Health Institute will leverage existing data and biospecimens from the 50+ year follow up of the Child Health and Development Studies birth cohort to conduct targeted and...
This $5,274,018 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The J. David Gladstone Institutes will study the susceptibility and resistance to the detrimental effects of the Apolipoprotein E4 (APOE4) genetic risk factor for Alzheimer's disease. The research aims to characterize neurophysiological, behavioral, and neuropathological differences between new APOE4 mouse lines...