The National Institute on Aging (NIA) awarded a 5-year, $2,278,304 Cooperative Agreement (CFDA 93.866 - Aging Research) to Emory University to investigate the biological mechanisms by which exposures to fine particulate matter (PM2.5) air pollution contribute to the development of Alzheimer's disease and related dementias (ADRD). The project, titled "IMPACT-ADRD: Investigating the Multi-omics Perturbations Associated with Complex Environmental Toxicants and Their Contribution to Alzheimer's...
This Project Grant from the National Institutes of Health's National Institute on Aging will fund research totaling $4,188,512 to the University of California, Davis from September 2022 through August 2025. The grant is part of the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research on aging processes and diseases affecting older populations. Specifically, the University of California, Davis will investigate the hypothesis that ultrafine particulate...
This Cooperative Agreement award, funded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), provides $2,175,074 to support a research project investigating the role of mid-life environmental toxicant exposures on the risk of Alzheimer's disease (AD) and AD-related dementias (ADRD). The project, led by the University of Pennsylvania, will leverage the ongoing Coronary Artery Risk Development in Young Adults (CARDIA) study to repeatedly measure...
The National Institute on Aging (NIA) awarded a $2,151,314 Project Grant to the University of Missouri System under the Aging Research program (CFDA 93.866) to conduct research on the effects of fine particulate matter (PM) exposure on small cerebrovascular inflammation and cognitive dysfunction. The 3-year project aims to investigate how PM exposure induces sex-specific inflammatory responses mediated by TNF-alpha in males and IL-6 in females, leading to cognitive impairment. The research...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,625,947 to the University of Rochester to conduct research on the relationship between air pollution-derived iron exposure, poverty-related stress, and Alzheimer's disease risk. The key objectives are to evaluate whether ambient and subway-level iron exposure leads to...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $419,011 to Emory University to develop innovative dimensionality reduction techniques for assessing the joint health effects of air pollution mixtures. The research aims to advance causal modeling approaches that preserve the relationships between air pollutants and health outcomes, in order to provide more accurate assessments of the public...
The National Institute on Aging (NIA) awarded a 5-year, $2,533,483 Cooperative Agreement (CFDA 93.866 - Aging Research) to Columbia University to prospectively examine the relationship between environmental toxicants and the risk of Alzheimer's disease (AD) and AD-related dementias (ADRD). The project will leverage the existing Diabetes Prevention Program Outcomes Study (DPPOS) AD/ADRD cohort to conduct longitudinal untargeted exposomics, metabolomics, and measurements of metals, polyfluoroalkyl...
This Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,499,382 in funding to Duke University to advance research on the role of chemical exposures in Alzheimer's disease (AD) and related dementias. The project aims to expand coverage of the chemical exposome in blood and brain, and link identified signatures to brain aging, incident dementia, and AD. Key activities include metabolomics and lipidomics analyses, integrating exposome data...
This Project Grant award, funded by the National Institute on Aging (CFDA 93.866 Aging Research), supports a multi-domain (genetic, socio-behavioral, vascular) study to investigate risk factors and prediction of Alzheimer's disease (AD) and related dementias (ADRD) among middle-aged South Asians in India. The $12,847,914 award to Emory University will leverage the existing Precision-CARRS cohort to perform AD/ADRD phenotyping, characterize genetic risk, and develop machine learning models to...
The National Institute on Aging (NIA) has awarded a $3,925,264 Cooperative Agreement under the Aging Research (CFDA 93.866) Federal Grant Program to the University of New Mexico Health Sciences Center (UNM HSC). The award, titled "PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and Dementia", will fund a comprehensive preclinical program to investigate the impacts of environmental stressors such as wildfire smoke, microplastics, and heavy metals on the...
This $3,915,141 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will support research at Emory University to investigate the relationship between air pollution exposure, specifically fine particulate matter (PM2.5), and Alzheimer's disease and related dementias (AD/ADRD). The key objectives are to determine 1) which specific PM2.5 components are most neurotoxic, 2) the role of other common air pollutants like carbon monoxide and ozone, and 3) the biological mechanisms in the brain resulting from PM2.5 exposure. The research will leverage metabolomic analyses of blood and brain samples to map internal biological changes associated with air pollution and AD/ADRD development. Emory University will collaborate with the University of California, Davis on a sub-award to support this research. The project period runs from Sep 2024 to Apr 2029.