This Cooperative Agreement award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $4,422,126.00 in funding to the Regents of the University of Michigan to conduct research on the impact of exposure to toxic metals, such as lead, cadmium, and arsenic, and their interaction with genetic susceptibility in driving the development of Alzheimer's disease and related dementias (ADRD). The key objectives of this 5-year project are to:...
This Project Grant awarded by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will fund a comprehensive investigation into the impact of metals exposure on dementia, cognition, functioning, and neuropsychiatric symptoms. The $240,972 award, granted to the Regents of the University of Michigan, will enable the principal investigator, Dr. Xin Wang, to examine the associations between metals concentrations and the prevalence, incidence, and...
This federal Project Grant award of $822,643.00, awarded by the National Institute on Aging under the Aging Research program (CFDA 93.866), will fund a research project to investigate how chronic exposure to common environmental neurotoxicants like lead, cadmium, and arsenic impact brain aging and the risk of late-onset Alzheimer's disease (LOAD). The researchers at Boston University Medical Campus, the prime awardee, will use innovative mouse models developed by the Model-AD Consortium to study...
This U01 Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,122,961 to leverage novel mouse models to investigate the impact of toxic metal exposures on brain aging and Alzheimer's disease (AD) pathobiology. The multi-disciplinary project team, led by researchers from Boston University, The Jackson Laboratory, and Indiana University, will expose genetically modified mouse models carrying AD-related risk factors to lead, cadmium, and...
This Cooperative Agreement award, funded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), provides $2,175,074 to support a research project investigating the role of mid-life environmental toxicant exposures on the risk of Alzheimer's disease (AD) and AD-related dementias (ADRD). The project, led by the University of Pennsylvania, will leverage the ongoing Coronary Artery Risk Development in Young Adults (CARDIA) study to repeatedly measure...
The National Institute on Aging (NIA) awarded a $3,925,264 Cooperative Agreement under its Aging Research Federal Grant Program (CFDA 93.866) to the University of New Mexico's Health Sciences Center. The project, titled "PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and Dementia", will assess the neuropathological impacts of emerging environmental contaminants like wildfire smoke, microplastics, and heavy metals across different exposure timeframes...
This federal Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $784,998.00 in funding to Purdue University to elucidate gene-environment interactions that contribute to the development of Alzheimer's disease and related dementias (ADRD) in aging brains. The key objectives are to: Identify genetic risk factors that interact with developmental exposure to lead (Pb) to influence the etiology of ADRD. This will involve establishing and...
This $4,260,300 project grant from the National Institutes of Health's National Institute on Aging will fund research under the Aging Research program (CFDA 93.866) to investigate the association between in utero environmental exposures and life-course cognition and prodromal Alzheimer's disease in midlife. The Public Health Institute will leverage existing data and biospecimens from the 50+ year follow up of the Child Health and Development Studies birth cohort to conduct targeted and...
The University of Massachusetts Medical School (UMass Medical) was awarded a Cooperative Agreement grant totaling $1,658,220.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The project, titled "Examining the Effect of Cadmium Metal Exposure on Alzheimer's Disease Genetic Alleles Using Herpes Viral Infected Cerebral Organoids," will investigate the relationship between cadmium exposure, herpes simplex virus 1 (HSV-1) infection, genetic...
This Project Grant from the National Institutes of Health's National Institute on Aging will fund research totaling $4,188,512 to the University of California, Davis from September 2022 through August 2025. The grant is part of the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research on aging processes and diseases affecting older populations. Specifically, the University of California, Davis will investigate the hypothesis that ultrafine particulate...