This Cooperative Agreement award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), provides $4,422,126.00 in funding to the Regents of the University of Michigan to conduct research on the impact of exposure to toxic metals, such as lead, cadmium, and arsenic, and their interaction with genetic susceptibility in driving the development of Alzheimer's disease and related dementias (ADRD). The key objectives of this 5-year project are to:...
This three-year, $4.84 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research at The Johns Hopkins University to investigate the neurological effects and cumulative risk of neurodegenerative disease from exposure to metal mixtures. Specifically, the researchers will examine the biological mechanisms by which exposure to mixtures of lead, arsenic, cadmium, and chromium during adulthood and early development cause...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), provides $429,000 in funding to the University of Texas Health Science Center at Houston (UTHealth) to investigate the role of metal regulatory transcription factor-1 (MTF-1) in neurodegeneration and dementias. The key research objectives are to determine whether aberrant MTF-1 activation is necessary and sufficient for driving neurodegeneration in fly models of...
The National Institute on Aging (NIA) awarded a $3,925,264 Cooperative Agreement under its Aging Research Federal Grant Program (CFDA 93.866) to the University of New Mexico's Health Sciences Center. The project, titled "PRE3BAD: Preclinical Research on Emerging Environmental Exposures, Brain Aging, and Dementia", will assess the neuropathological impacts of emerging environmental contaminants like wildfire smoke, microplastics, and heavy metals across different exposure timeframes...
This $338,527 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to understand the role of inhibitory interneurons in the pathophysiology of Alzheimer's disease (AD) and related dementias (ADRD). The key objectives are to: 1) Identify disrupted interneuron gene expression in post-mortem AD brain tissue, 2) Characterize inhibitory dysfunction in AD-derived induced interneurons in vitro, and 3) Assess the impact of transplanting healthy...
The University of Massachusetts Medical School (UMass Medical) was awarded a Cooperative Agreement grant totaling $1,658,220.00 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The project, titled "Examining the Effect of Cadmium Metal Exposure on Alzheimer's Disease Genetic Alleles Using Herpes Viral Infected Cerebral Organoids," will investigate the relationship between cadmium exposure, herpes simplex virus 1 (HSV-1) infection, genetic...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,915,141 to Emory University to investigate the link between air pollution exposure, the blood and brain metabolome, and their effects on Alzheimer's disease and related dementias. The project aims to answer three key questions: 1) which components of fine particulate matter (PM2.5) are most neurotoxic, 2) the role of other air pollutants like carbon monoxide, nitrogen dioxide, and ozone,...
This $4,260,300 project grant from the National Institutes of Health's National Institute on Aging will fund research under the Aging Research program (CFDA 93.866) to investigate the association between in utero environmental exposures and life-course cognition and prodromal Alzheimer's disease in midlife. The Public Health Institute will leverage existing data and biospecimens from the 50+ year follow up of the Child Health and Development Studies birth cohort to conduct targeted and...
This Project Grant from the National Institutes of Health's National Institute on Aging will fund research totaling $4,188,512 to the University of California, Davis from September 2022 through August 2025. The grant is part of the Aging Research program (CFDA 93.866), which supports biomedical, social, and behavioral research on aging processes and diseases affecting older populations. Specifically, the University of California, Davis will investigate the hypothesis that ultrafine particulate...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program provides $1,625,947 to the University of Rochester to conduct research on the relationship between air pollution-derived iron exposure, poverty-related stress, and Alzheimer's disease risk. The key objectives are to evaluate whether ambient and subway-level iron exposure leads to...