The National Institute on Aging (NIA) awarded a $2,329,825 Project Grant (CFDA 93.866 - Aging Research) to Emory University to investigate the effects of air pollution on Alzheimer's disease and related dementias. The research aims to identify the specific components of fine particulate matter (PM2.5) and other air pollutants that are most neurotoxic, as well as understand the biological pathways linking air pollution exposure to brain health and cognitive decline. The project will leverage...
The National Institutes of Health National Institute on Aging awarded a $4.3 million project grant to the University of California Irvine to fund research on the neurotoxicity of particulate matter and its interaction with APOE in neurodegeneration from September 2022 through August 2025. The grant supports research to comprehensively evaluate the neurotoxicity of ambient particulate matter and its environmental risk in a novel mouse model of late-onset Alzheimer's disease. Researchers will also...
The National Institute on Aging (NIA) awarded a $2,151,314 Project Grant to the University of Missouri System under the Aging Research program (CFDA 93.866) to conduct research on the effects of fine particulate matter (PM) exposure on small cerebrovascular inflammation and cognitive dysfunction. The 3-year project aims to investigate how PM exposure induces sex-specific inflammatory responses mediated by TNF-alpha in males and IL-6 in females, leading to cognitive impairment. The research...
This Cooperative Agreement, awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866), provides $2,278,304 in funding to Emory University to investigate the impact of fine particulate matter (PM2.5) air pollution exposure on the risk and underlying biological mechanisms of Alzheimer's disease and related dementias (AD/ADRD). The project, titled "IMPACT-ADRD: Investigating the Multi-Omics Perturbations Associated with Complex...
This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $1,625,947.00 to the University of Rochester to conduct research on the link between air pollution-derived iron exposure, poverty-related stress, and Alzheimer's disease risk. The key objectives of this research project are to: 1) Evaluate whether air pollution exposure,...
This $4,260,300 project grant from the National Institutes of Health's National Institute on Aging will fund research under the Aging Research program (CFDA 93.866) to investigate the association between in utero environmental exposures and life-course cognition and prodromal Alzheimer's disease in midlife. The Public Health Institute will leverage existing data and biospecimens from the 50+ year follow up of the Child Health and Development Studies birth cohort to conduct targeted and...
The National Institute on Aging (NIA) awarded a $2,288,327 Project Grant (CFDA 93.866 - Aging Research) to the University of California, San Diego (UCSD) on August 15, 2024. The grant funding will support research to investigate the early determinants and pathogenesis of Alzheimer's disease (AD) using age-equivalent neurons derived from mild cognitive impairment (MCI) patient samples. The research teams will utilize patient-derived induced neurons to study how polygenic risk factors and...
This federal Cooperative Agreement award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,827,512 to the Scripps Research Institute to study the role of aberrant protein S-nitrosylation in mediating gene-environment interactions that contribute to the development of Alzheimer's disease (AD) and AD-related dementias (ADRD). The key objectives are to: 1) Determine the effects of air pollution exposure, specifically fine particulate matter and nitric oxide species, on...
The National Institute on Aging (NIA), under the federal Aging Research grant program (CFDA 93.866), awarded a $1,703,626 Project Grant to the University of North Dakota (UND) Division of Research & Economic Development. The grant, effective September 1, 2023 through August 31, 2026, will fund research to investigate the potential link between lung dysfunction and the progression of Alzheimer's disease (AD). Key objectives include: Characterizing the temporal changes in AD-related lung...
This federal Project Grant award of $1,205,827.00 was provided by the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research. The award, with a start date of August 1, 2024 and ultimate completion date of June 30, 2029, will support a study examining the role of the "exposome" (environmental exposures) as a risk factor for Alzheimer's disease among diverse racial/ethnic populations. The project will utilize blood samples from 3,000 participants in the ongoing...