The National Institute on Aging, part of the Department of Health and Human Services, awarded $2,459,487 under its Aging Research grant program (CFDA 93.866) to Seattle Children's Hospital on May 15, 2022 for a project concluding on April 30, 2025. The award will support research using in vivo multi-photon imaging techniques to investigate age-related impairment of venous drainage in deep gray and white matter regions of the mouse brain. Specifically, the researchers will test hypotheses about...
The federal Project Grant award R21AG083716 in the amount of $891,623.00 was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to Cornell University. The funding supports the development and application of novel genetically engineered secreted tracers (GESTS) to map fluid transport and waste clearance mechanisms in the brain, with a focus on understanding amyloid-beta and Alzheimer's disease pathways. The award enables the research team to create...
This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
This $4.49 million project grant from the National Institutes of Health's National Institute on Aging will fund research at The Washington University to investigate the relationship between amyloid plaque deposition, cellular metabolic dysfunction, and functional brain organization in Alzheimer's disease (AD) mice models. Over three years, the researchers will use multi-photon fluorescence lifetime imaging microscopy, multi-parametric photoacoustic microscopy, and wide-field optical imaging to...
This federal Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $640,906 to the University of Wisconsin - Madison to elucidate the cerebrovascular disease pathways that contribute to cognitive decline. The project aims to utilize advanced neuroimaging techniques to characterize the impact of vascular disease processes, including vascular stiffness and decreased flow tone, on brain tissue integrity and cognition in the presence...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $640,000 to Northeastern University to develop and apply new intravital microscopy techniques. The goal is to gain greater insight into the effects of gamma entrainment, a promising non-pharmacological neuromodulation technique for Alzheimer's disease (AD) and other brain pathologies. The project will focus on characterizing how gamma entrainment influences cerebral energy metabolism and...
This Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $10,847,672 to the J. David Gladstone Institutes, a non-profit biomedical research organization, to investigate the vascular-immune mechanisms underlying cerebral amyloid angiopathy (CAA) and Alzheimer's disease pathology. The research aims to elucidate the key microglial mechanisms regulating the formation of vascular CAA versus parenchymal amyloid-beta plaques, define single-cell and...
This $1,919,387 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to assess the impact of reduced cerebral blood flow and neurovascular coupling on brain function and homeostasis in aging. The project aims to use a novel computational homeostatic modeling (HOMOD) approach to calculate regional brain tissue and capillary blood levels of CO2, O2, and pH in young and elderly subjects. The research will utilize calibrated fMRI and fMRS...
The National Institute on Aging (NIA) awarded a $2,547,870 Cooperative Agreement (CFDA 93.866 - Aging Research) to Weill Medical College of Cornell University to develop a high-resolution, cost-effective, portable, and upright brain PET scanner for early diagnosis of Alzheimer's disease. The project aims to integrate an ultra-high resolution electromagnetic motion tracker with the PRISM-PET brain scanner to enable quantitative assessment of tau deposition in early mild cognitive impairment....
This federal Project Grant award R21NS135390 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders CFDA program (93.853), provides $444,555.00 to Cornell University for a research project titled "Reduced Alzheimer's Disease Progression and Neutrophil Adhesion via Competition Using Neutrophil-Derived or Engineered Nanoparticles." The project aims to develop a novel therapeutic...