Project Grant R21AG083716
Award Date
9/1/23
Completion Date
8/31/25
Dollars Obligated
$892K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Ithaca, NY, USA
Similar Awards
The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
This federal Project Grant award, with an ID of R21AG089268, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The $664,000 award, effective from August 15, 2024 to May 31, 2026, will fund research at the University of Southern California to investigate the role of meningeal lymphatic dysfunction in Alzheimer's disease pathogenesis. The key aims of the project are to determine whether craniosynostosis, a craniofacial disorder, is a risk factor for...
This federal Project Grant award, valued at $131,027.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866) to The Leland Stanford Junior University. The award aims to study neuronal proteostasis, the maintenance of protein health, during brain aging and Alzheimer's disease (AD). The key products and services to be delivered under this grant include: Conducting in vivo experiments using a novel bioorthogonal non-canonical amino acid tagging (BONCAT)...
This $200,323 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of South Florida to investigate the aggregation of amyloid-beta (Aβ) peptides during metabolic stress and spreading depolarization events in the brain. The project will utilize multiscale modeling, high-resolution microscopy, antibody staining, and paralysis phenotype testing in C. elegans to determine how physiochemical changes...
This $717,709 federal Project Grant award, provided by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research aimed at understanding the cellular mechanisms underlying the propagation of misfolded tau protein aggregates in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The grant will enable a research team at Weill Medical College of Cornell University to utilize advanced proteomic and transcriptomic techniques, in combination with novel...
The federal Project Grant award R21AG087875, totaling $239,122.00, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to Yale University. The grant supports a team science approach to integrate machine-learning models and functional genomics to study aging in the context of Alzheimer's disease. Key objectives include developing a cell-type specific regulatory network model for normal brain aging and Alzheimer's brain aging, and generating an empirical dataset to...
This federal Project Grant award of $437,875.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of California, San Diego (UCSD) will support a comprehensive study to quantify the lifetimes of neurovascular proteins in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The primary objectives are to: 1) employ stable isotope labeling, vessel isolation, and mass spectrometry proteomics to measure neurovascular protein lifetimes...
This federal Project Grant award R21NS135390 from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders CFDA program (93.853), provides $444,555.00 to Cornell University for a research project titled "Reduced Alzheimer's Disease Progression and Neutrophil Adhesion via Competition Using Neutrophil-Derived or Engineered Nanoparticles." The project aims to develop a novel therapeutic...
This $679,424 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports preclinical studies to evaluate the efficacy of a novel nanoligomer treatment for reducing neuroinflammation and protecting against cognitive decline in mouse models of brain aging and Alzheimer's disease. The research aims to determine the ideal application of the NF-kB/NLRP3-targeted nanoligomer treatment, whether for prevention during aging or treatment of pathology, and to...
This $654,238 Project Grant award from the National Institute on Aging (NIA) under CFDA Program 93.866 - Aging Research supports research to investigate the role of senescent cells in brain aging and the development of Alzheimer's disease and related dementias (ADRD). The project aims to generate high-resolution spatial omics data from ADRD brains and mouse models to identify molecular changes in the microenvironment of senescent neurons compared to healthy neurons. The work will be conducted by...