This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $640,000 to Northeastern University to develop and apply new intravital microscopy techniques. The goal is to gain greater insight into the effects of gamma entrainment, a promising non-pharmacological neuromodulation technique for Alzheimer's disease (AD) and other brain pathologies. The project will focus on characterizing how gamma entrainment influences cerebral energy metabolism and microvascular hemodynamics in mouse models of AD. By developing advanced microscopy methods, the researchers aim to explore changes to cellular signaling, metabolism, and microvascular blood flow in response to gamma entrainment. The findings are expected to improve understanding of the technique's mechanisms of action and guide strategies to optimize its utility for treating AD patients. The award period runs from September 15, 2024 to May 31, 2026.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $240.0k | 5/2/25 | ||
| Not listed | $200.0k | 9/10/24 | ||
| Not listed | $200.0k | 9/10/24 |