This National Science Foundation (NSF) Project Grant Award under the Computer and Information Science and Engineering (CFDA 47.070) program provides $225,000 to the University of Massachusetts (UMass) to develop closed-loop hybrid intelligence (HI) systems that integrate optogenetic neuromodulation and neuromorphic hardware. The key products of this 3-year project (6/15/2025 - 5/31/2028) include: Optogenetic cell interfaces composed of light-emitting diodes and microelectrodes co-designed with...
The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct emission...
The University of Minnesota was awarded a $3,972,414 Project Grant from the National Institute of Neurological Disorders and Stroke within the Department of Health and Human Services to develop an electro-optical multiphoton microscope. The microscope will leverage advances in electro-optical beam deflection to enable random-access multiphoton interrogation of neurons and synapses with sub-microsecond access times. This will allow neuroscientists to collect the simultaneous recordings needed...
The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $1,852,675 under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to the University of California, Los Angeles from August 1, 2022 to July 31, 2025. The award will support the development of light field tomographic microscopy for kilohertz volumetric imaging of neuronal action potentials in awake behaving mice. Specifically, the...
The U.S. National Institutes of Health (NIH) awarded a $1,671,116 Cooperative Agreement grant under the Trans-NIH Research Support (CFDA 93.310) program to The Washington University in St. Louis. The 3-year grant, running from September 2023 to August 2026, aims to develop a novel two-component optogenetic system for reversibly controlling the activity of user-defined synaptic connections between specific cell types in the brain. The project will involve engineering light-sensitive G...
The Johns Hopkins University was awarded a $2,008,605 Project Grant under the National Institute of Neurological Disorders and Stroke's 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372). The grant funding will support the development of an "Autonomous Rapidly Adaptive Multiphoton Microscope for Neural Recording and Stimulation." This adaptive multiphoton microscope system will leverage hybrid volumetric scanning,...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $187,831 Project Grant (R21EB035306) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the University of California, Davis. This grant supports the development of a novel miniature microscope that can simultaneously perform two-photon calcium imaging and two-photon optogenetic manipulation of neural activity in freely-behaving mice. The project...
This Project Grant from the National Institutes of Health's National Institute of Neurological Disorders and Stroke will fund the development of advanced tools for genetically targeted all-optical electrophysiology in behaving mice. Specifically, the $4,381,836 award to President and Fellows of Harvard College, doing business as Harvard University, will support efforts to co-develop two-photon excitable genetically encoded voltage indicators and a new type of two-photon voltage-imaging...
The National Institutes of Health (NIH) awarded a $1,385,000 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Allen Institute, a non-profit research organization, to develop novel techniques for measuring the input-output operations of individual neurons in the mouse cortex. The project aims to overcome challenges in understanding how neurons in the mammalian brain transform their synaptic inputs into outputs, which is critical for designing effective brain-machine...
The U.S. National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,860,153 Cooperative Agreement grant to The Regents of the University of California, San Francisco (UCSF) under the NIBIB's "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program. The key objectives of this 3-year project, starting August 2024, are to establish scalable tools that combine spatial transcriptomics and connectomics methods to...