Project Grant RF1NS128488

Award Date 8/1/22
Completion Date 7/31/25
Dollars Obligated $1.9M
Federal Grant Program
93.372
Assistance Type
Project Grant
Place of Performance
Los Angeles, CA 90095, USA
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The award will support the development of light field tomographic microscopy for kilohertz volumetric imaging of neuronal action potentials in awake behaving mice. Specifically, the university will adapt light field tomography for 3D fluorescence microscopy and combine it with genetically encoded voltage indicators to provide high-speed volumetric imaging of 3D neuronal networks. When linked to animal behavior experiments, this work aims to correlate neuronal activity to behavior at the single-cell level. The university will also subaward $152,675 to the University of Arizona to develop the optical systems, fabricate and test components, and provide integration and evaluation support.

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