Project Grant RF1NS126076

Award Date 9/1/22
Completion Date 8/31/25
Dollars Obligated $3.6M
Federal Grant Program
93.372
Assistance Type
Project Grant
Place of Performance
California, USA
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This federal Project Grant award of $354,600.00 from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), will support the development of novel methodologies for simultaneous, distributed perturbation of multiple cortical regions using patterned light in head-fixed mice. The goal is to infer how large-scale patterns of cortical activity underlie...
The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $1,852,675 under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to the University of California, Los Angeles from August 1, 2022 to July 31, 2025. The award will support the development of light field tomographic microscopy for kilohertz volumetric imaging of neuronal action potentials in awake behaving mice. Specifically, the...
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This $5.976 million project grant from the National Institutes of Health's National Institute of Child Health and Human Development will fund the development of an all-optical holographic brain interface capable of precisely and bidirectionally altering neural population activity across large volumes of brain tissue with high speed and resolution. Awarded to the University of California, Berkeley on September 1, 2022 for a three-year period ending August 31, 2025, the grant will support the...
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The National Institutes of Health National Institute of Neurological Disorders and Stroke awarded $3.6 million under the 21st Century Cures Act Brain Research through Advancing Innovative Neurotechnologies program (CFDA 93.372) to Stanford University. The project grant will support development of a noninvasive, dynamically programmable in vivo light source for rapid brain-wide optogenetic screening. Specifically, the awardee aims to develop mechanoluminescent nanoparticles with distinct emission spectra matching different opsin variants and favorable circulation properties. The nanoparticles will be activated using focused ultrasound to locally emit light for optogenetic stimulation of neurons without invasive brain implantation. The funding will enable characterization of the nanoparticles' properties to construct an intravital light source for on-demand emission patterns in live mouse brains. This will allow optogenetic stimulation of multiple brain regions in the same animal to rapidly screen their contributions to behaviors like drug-seeking.

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