This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $156,656 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct advanced functional MRI (fMRI) studies of cerebral cortical layers in the human brain. The research aims to validate the use of "linescan fMRI," a high-resolution technique that can map brain activity across individual...
This federal Project Grant award, funded by the National Institute on Aging (CFDA 93.866 - Aging Research), provides $1,812,929.00 to the New Jersey Institute of Technology (NJIT) to conduct a comprehensive study on the functional networks of white matter in Alzheimer's disease (AD) and their associations with cognitive decline. The 5-year project, which runs from August 1, 2024 to April 30, 2029, aims to characterize white matter resting-state functional magnetic resonance imaging (WM-rsfMRI)...
This Project Grant award of $354,145 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a longitudinal study to characterize functional brain network changes across the mouse lifespan. Using awake resting-state fMRI, the researchers at Columbia University's Health Sciences Division will quantify alterations in brain network organization, particularly network segregation, and relate these changes to behavioral measures such as memory, learning, and sensory-motor...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $390,616 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to the Regents of the University of Michigan for the development of layer-specific functional magnetic resonance imaging (fMRI) techniques for clinical 3 Tesla scanners. The goal is to improve signal-to-noise ratio and reduce scan time for layer-specific fMRI, which currently...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Trustees of Boston University, doing business as Boston University Medical Campus, provides $2,330,859.00 in funding to study age-related changes in brain network connectivity and their relationship to cognitive decline. The 3-year project aims to use multimodal neuroimaging, single-cell transcriptomics, electrophysiology, and neural tract-tracing in a rhesus monkey model to delineate how...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) federal grant program, is for $476,993 over a period of 2 years from August 1, 2024 to July 31, 2026. The project aims to develop novel qualitative and quantitative methods to measure white matter hyperintensities (WMH) on low-field portable MRI (PMRI) devices. This will involve creating a WMH...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $4,692,540 to Northwestern University to develop advanced MRI techniques for directly assessing cerebral microvascular pulsatility, a key indicator of cerebral small vessel disease (CSVD). The research aims to create clinically applicable MRI tools that can improve understanding of how microvascular dysfunction contributes to CSVD and related conditions like Alzheimer's disease and vascular...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $4,638,424 to the University of California, San Diego from August 1, 2022 to July 31, 2025. The grant will support research developing novel quantitative magnetic resonance imaging techniques to directly image myelin and quantify myelin content and properties in the brain. Specifically, the researchers will use ultra-short echo time sequences with echo...
This $4.8 million project grant from the National Institutes of Health's National Institute on Aging Aging Research program (CFDA 93.866) will fund research into vascular contributors to blood-brain barrier permeability and regional white matter hyperintensity progression in asymptomatic individuals ages 40-50. The Johns Hopkins University will study how periventricular and deep white matter hyperintensities independently progress and influence clinical outcomes, and how increasing blood-brain...
This $4.46 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866) to develop a new in vivo magnetic resonance imaging biomarker for early detection of Alzheimer's disease neurodegeneration. Specifically, the awardee, Washington University, will utilize quantitative gradient recalled echo MRI techniques to identify two types of hippocampal tissue in preclinical and mild...