Project Grant R01AG092528
- Federal Project Grant Award Summary The National Institute on Aging awarded the University of Virginia a $522,167 Project Grant, effective August 1, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). The award supports research investigating mechanisms of ribosomal DNA (rDNA) instability during aging, with the objective of understanding how genomic instability contributes to the aging process. The research focuses on characterizing the roles of the FOB1 protein and...
- Federal Grant Award Summary The University of Virginia received a $726,452 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 15, 2025, with a completion date of April 30, 2029. This research award funds the development and application of computational and experimental methods to model intra- and inter-cellular signaling networks mediating Transient Receptor Potential Cation Channel,...
- Federal Grant Award Summary The University of Virginia received a $759,095 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) on May 15, 2025, with completion targeted for February 28, 2030. The award funds research and development of magnetic resonance (MR) image-guided focused ultrasound (FUS) technology combined with microbubbles to selectively deliver SHIP-1 neutralizing therapies across the blood-brain barrier to brain-resident microglia. The...
- Federal Project Grant Award Summary The University of Missouri System received a $429,394 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded December 15, 2025, with completion targeted for November 30, 2027. This research initiative addresses heart failure with preserved ejection fraction (HFpEF) in aging populations with comorbid conditions such as obesity and hypertension. The project focuses on investigating LARP6 (LA...
- Federal Grant Award Summary The University of Virginia received an $806,901 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective August 1, 2025, with completion targeted for May 31, 2030. This research grant funds investigation into oxidation-specific epitope immunoglobulin A (IgA) responses in idiopathic pulmonary fibrosis (IPF) pathogenesis. The research program will examine the role of IgA...
- Federal Grant Award Summary The University of Virginia received $802,611 in project grant funding from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 15, 2025, with completion targeted for August 31, 2029. This grant supports the development of improved cardiac magnetic resonance imaging (MRI) methods to quantify epicardial adipose tissue (EAT) composition and demonstrate their clinical application in...
- Federal Project Grant Award Summary The University of Virginia received a $644,997 Project Grant award dated August 21, 2025, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports research to identify and validate plasma proteomic biomarkers for early and late-stage pulmonary fibrosis, with completion targeted for May 31, 2030. This research addresses a critical gap in idiopathic pulmonary fibrosis (IPF)...
- Federal Grant Award Summary The University of Virginia received a $666,319 Project Grant award dated August 18, 2025, from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The project, titled "Nanotherapeutic Strategies for the Treatment of Chronic Chagas Disease," will be conducted through May 31, 2029, and focuses on developing and validating nanotherapy platforms to address critical treatment challenges...
- Federal Grant Award Summary The University of Virginia received a $732,261 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), effective September 15, 2025, through June 30, 2029. The award funds research to identify and validate genetic factors contributing to central obesity through functional analysis of genome-wide association study (GWAS) loci. The project leverages multi-ethnic, multi-omic data...
- Federal Grant Award Summary The National Institute on Aging awarded Duke University a $680,818 Project Grant effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866) to conduct the INFUSE HFPEF (Iron Needed for Function and Undesirable Symptoms in Elderly with Heart Failure with Preserved Ejection Fraction) study. This double-blind, placebo-controlled randomized clinical trial will evaluate the efficacy of intravenous iron supplementation in 300...
The University of Virginia received a $689,148 Project Grant award from the National Institute on Aging (CFDA 93.866, Aging Research) with an award date of February 1, 2026, and completion date of January 31, 2031. This research project investigates the profibrotic effects of hematopoietic Y chromosome loss (mLOY) in heart failure with preserved ejection fraction (HFpEF). The research will explore the clinical, causal, and mechanistic relationships between mLOY—the most prevalent postzygotic mutation in males—and HFpEF, with the objective of understanding sex-specific pathological mediators that may explain why males with HFpEF experience worse morbidity and mortality outcomes compared to females despite similar disease prevalence. The deliverables under this grant will include scientific findings addressing whether mLOY in the hematopoietic system contributes to cardiac fibrosis and diastolic dysfunction in males, supported by both human clinical data and experimental mouse models. The research is designed to yield mechanistic insights that could inform sex-specific treatment approaches for HFpEF, a prevalent yet underserved condition with limited therapeutic options for male patients. Work will be conducted at the University of Virginia's Charlottesville, Virginia facility, supporting the National Institute on Aging's mission to advance understanding of age-related diseases and develop preventive and therapeutic strategies for aging populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $689.1k | 1/29/26 |