Project Grant R01AG093729
- Federal Grant Award Summary Brigham and Women's Hospital has been awarded $6.47 million by the National Institute on Aging under the Aging Research program (CFDA 93.866) to continue funding for the Ante-Amyloid Treatment of Alzheimer's Disease (A3) Trial and the Alzheimer Plasma Extension (APEX) Study. The award, effective September 1, 2025 through August 31, 2030, supports a Phase IIB clinical trial investigating low-dose lecanemab, an amyloid-removing monoclonal antibody, in participants at...
- Federal Grant Award Summary Brigham & Women's Hospital received a $3.69 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 15, 2025, with a completion date of September 14, 2029. The award funds development of specialized large language models (LLMs) designed to extract Alzheimer's disease and related dementias (ADRD)-relevant clinical phenotypes from electronic health records (EHRs). The project addresses a critical...
- Federal Grant Award Summary Massachusetts General Hospital's Research Management Division received a $1.37 million Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective March 1, 2026, through December 31, 2029. This four-year methodology grant funds research to assess the utility of 64-Copper-Fibrin-Binding-Probe-8 positron emission tomography (FBP8 PET) for detecting and quantifying pathological fibrin in the brain within a...
- Federal Project Grant Award Summary The National Institute on Aging (NIA), operating under the Aging Research program (CFDA 93.866), awarded a $470,000 Project Grant to Trustees of Tufts College (doing business as Tufts University School of Medicine) for the period February 1, 2026 through January 31, 2028. The award supports research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the impact of single and...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a Project Grant totaling $511,574 to The Trustees of Columbia University in the City of New York (Health Sciences Division) under the Aging Research program (CFDA 93.866), effective July 1, 2026, with completion targeted for April 30, 2031. This project develops statistical methods and computational approaches to identify heterogeneous treatment effects (HTEs) of interventions targeting modifiable Alzheimer's...
- Federal Grant Award Summary The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a $3.28 million Project Grant to Harvard T.H. Chan School of Public Health on September 15, 2025, with completion targeted for August 31, 2029. This research initiative addresses the interplay between herpesvirus infection, immune responses, apolipoprotein E (APOE) genotype, and tau-pathology development in Alzheimer's disease (AD). The primary deliverable is scientific...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of South Florida $3.297 million under the Aging Research program (CFDA 93.866) for a four-year project period (September 1, 2025 – August 31, 2029) to develop novel peptidomimetic biomaterials that inhibit amyloid-beta (Aβ42) aggregation in Alzheimer's disease. The research deliverables include the rational design and characterization of structurally related analogues to a lead compound that stabilizes Aβ...
- Federal Grant Award Summary Brigham & Women's Hospital Inc. received a $492,250 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 15, 2025, with completion targeted for August 31, 2027. The research project investigates whether regulatory T cells (Tregs) are dysfunctional in Alzheimer's disease and, if so, whether restoring Treg functionality could mitigate disease progression. The project builds upon existing evidence...
- Federal Grant Award Summary The National Institute on Aging awarded Columbia University's Health Sciences Division a $6.93 million Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to develop a multi-organ artificial intelligence-derived endophenotype (MAE) chart for personalized Alzheimer's disease and aging research. The four-year project, extending through July 31, 2029, will integrate large-scale multi-omics and multi-organ biomedical data with advanced...
- Federal Grant Award Summary The National Institute on Aging (CFDA 93.866 – Aging Research) awarded The Feinstein Institutes for Medical Research a $2.56 million Project Grant on May 15, 2026, to investigate the molecular mechanisms by which extracellular cold-inducible RNA-binding protein (ECIRP) induces neurotoxic astrocytes and their role in Alzheimer's disease (AD) pathogenesis. The research will evaluate ECIRP as a therapeutic target and assess the efficacy of M3, a small anti-ECIRP...
Funding Agency: National Institute on Aging (NIA) Brigham and Women's Hospital will conduct a genetic and plasma biomarker investigation to identify predictors of treatment response and adverse effects in Alzheimer's disease (AD) patients receiving anti-amyloid-beta (anti-AB) monoclonal antibody therapies, specifically lecanemab and donanemab. The research will enroll approximately 250 participants and leverage innovative genomics approaches and blood-based biomarkers to predict amyloid-beta (AB) clearance rates, amyloid-related imaging abnormalities (ARIA-E and ARIA-H), and clinical progression outcomes. By identifying genetic and plasma biomarkers associated with treatment efficacy and safety, this project aims to enable earlier, more cost-effective identification of patients most likely to benefit from anti-AB therapy while minimizing exposure to patients at high risk for serious adverse events, thereby improving resource utilization and clinical outcomes in precision AD therapeutics. The research addresses significant heterogeneity in treatment response to currently approved AD therapies, where over 20 percent of treated patients remain amyloid-positive despite extended treatment and unpredictable serious side effects require frequent and expensive brain magnetic resonance imaging monitoring. This investigation will define microglia and astrocyte-specific polygenic AD risk factors and their association with treatment response, supporting the clinical translation of precision medicine approaches in AD management.Federal Grant Award Summary
Federal Grant Program: Aging Research (CFDA 93.866)
Award Amount: $751,786
Award Date: July 15, 2026
Project Completion: April 30, 2031
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $751.8k | 7/15/26 |