Project Grant RF1AG090341
- The National Institute on Aging, under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $3,754,882 project grant to Mayo Clinic to investigate the effects of premenopausal bilateral oophorectomy (PBO) on imaging biomarkers of Alzheimer's disease and cerebrovascular disease in women. The project aims to enroll 400 women, including an African American cohort from Mayo Clinic Florida, to study how the abrupt disruption of ovarian hormones before natural menopause impacts the...
- This federal Project Grant of $441,100, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research), will support research to characterize handwriting patterns in patients with atypical Alzheimer's disease and frontotemporal dementia. The project aims to explore how digital tools can be used to collect and analyze handwriting samples, with the goal of improving timely and accurate diagnosis of these neurodegenerative diseases. The grant was awarded to the Mayo Clinic, a renowned...
- This $3,687,278 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to optimize the validity of comparative effectiveness research in Alzheimer's disease and related dementias using large language models. The grant supports research at Brigham & Women's Hospital, a subsidiary of the Partners Healthcare System, to build novel large language models that can extract clinically relevant phenotypes from electronic health record data. This will...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at Iowa State University to study the relationship between the menopause transition and accelerated cerebrovascular aging in women. The $405,155 award, commencing on September 1, 2025, will support a 2-year project to determine differences in cerebral pulsatility, cerebral blood flow, and associated vascular contributors between pre-, peri-, and post-menopausal women. The research aims...
- The National Institute on Aging (NIA) awarded a $3,281,385 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, San Diego (UCSD) to leverage 30 years of Alzheimer's disease clinical trials data. The goal is to examine the role of specific patient phenotypes, such as sex/gender, APOE4 status, and polygenic hazard scores, on response to drug or lifestyle interventions. The project will analyze data from 14,602 participants across multiple...
- This $287,118 Project Grant was awarded on September 1, 2023 by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) grant program. The grant will fund the development of techniques to use deep transfer learning and multimodal data, including brain MRIs, genetic information, and cognitive tests, to enable the early detection and forecasting of Alzheimer's disease progression. The University of Massachusetts (UMass), as the prime awardee, will create an end-to-end...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $474,092 Project Grant under the Aging Research federal grant program (CFDA 93.866) to One Health Studio LLC in San Francisco, CA. The grant supports the development and evaluation of the "FLOURISH ALL" platform, an AI-enabled digital health solution aimed at reducing Alzheimer's disease and related dementia (ADRD) risk in midlife women through stress management and promotion of...
- The National Institute on Aging (NIA) awarded a $1,558,726 Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh. The grant, titled "MENOBRAIN: A Longitudinal Investigation of Menopause and Brain Health," will conduct a 5-year study to elucidate the brain and cognitive changes that occur during the perimenopause phase of the menopause transition, and the factors contributing to these changes. The study will recruit 224 women in the late...
- This $4,765,698 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) will fund a research study by the University of California, Santa Barbara to investigate the effects of endocrine aging on spatial navigation ability and its neuronal systems. The project will enroll 240 cognitively normal midlife adults, with a balanced distribution of pre-, peri-, and post-menopausal women, and use immersive virtual environments and brain imaging to elucidate how...
- The National Institute on Aging, under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $148,050 project grant to Northwestern University to investigate sex-specific hypothalamic pathology and immune infiltration in Alzheimer's disease. This 3-year project, starting on September 27, 2025 and completing on May 31, 2028, aims to: 1) utilize single-cell fixed RNA profiling to identify and evaluate cell-specific transcriptomic alterations in the Alzheimer's disease hypothalamus,...
This $3,377,863 Project Grant was awarded on September 15, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research) to the Mayo Clinic in Minnesota. The objective is to analyze women-specific health patterns from electronic health records to address diagnostic disparities in the progression of cognitive impairment and dementia. The project aims to leverage precision medicine approaches to better understand how factors unique to women, such as menopause and pregnancy, may impact cognitive health and dementia risk. The research seeks to inform more effective diagnostic, management, and predictive tools for Alzheimer's disease and other dementias, particularly for the growing aging population. The grant will fund this 4-year project through its completion on September 14, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.4m | 9/8/25 |