Project Grant R01AG093767
Award Date
5/15/25
Completion Date
4/30/30
Dollars Obligated
$2M
Federal Agency
National Institute on Aging
Awardee
Mayo Clinic (Y2K4F9RPRRG7)
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Minnesota, USA
Similar Awards
The National Institute on Aging (NIA) awarded a $1,558,726 Project Grant under the Aging Research program (CFDA 93.866) to the University of Pittsburgh. The grant, titled "MENOBRAIN: A Longitudinal Investigation of Menopause and Brain Health," will conduct a 5-year study to elucidate the brain and cognitive changes that occur during the perimenopause phase of the menopause transition, and the factors contributing to these changes. The study will recruit 224 women in the late...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), is focused on investigating the association between the Alzheimer's disease (AD) risk gene APOE4 and the menopause-related hormone follicle-stimulating hormone (FSH) in the initiation and progression of AD, particularly in women. The $564,530 award to Emory University will support research to explore how APOE4 may facilitate AD pathology in women by interacting with FSH-induced...
This $1,215,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to characterize the genetic architecture underlying the age of amyloid-beta (Aβ) positivity onset in Alzheimer's disease (AD). The award recipient, Mayo Clinic Arizona, will leverage advanced imaging and genetic analysis techniques, including artificial intelligence models, to analyze Aβ positron emission tomography (PET) data from over 16,000 participants in the AD...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $815,215 to Yale University to conduct a multimodal imaging study examining sex-based contributors to vulnerability to Alzheimer's disease (AD). The study aims to leverage a new prospective cohort and open-source datasets to understand the impact of sex and sex-based factors, such as reproductive period and APOE genotype, on functional brain networks and the progression of tau pathology in...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $131,004 to The Leland Stanford Junior University to conduct research on the role of reproductive aging for racial differences in Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) from midlife to older age. The research project will harmonize longitudinal data from three cohorts totaling 25,051 women (30% Black) to comprehensively assess how early menopause, including...
This Project Grant award of $431,750 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to investigate the interaction between biological sex and APOE genotype in modulating Alzheimer's disease (AD) risk. The research will leverage human induced pluripotent stem cell lines with various APOE genotypes and sex chromosome complements to examine how APOE and sex influence amyloid-beta processing, tau hyperphosphorylation, and transcriptional changes...
This $4,517,210 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study by Tulane University to examine the relationship between reproductive history, lifetime metabolic exposures, and midlife cognition and brain function. The three-year project aims to: 1) assess reproductive history as a predictor of midlife cognition and cognitive decline; 2) examine reproductive history as a predictor of brain structural and functional outcomes;...
The National Institute on Aging (NIA) awarded a $1,473,241 Project Grant under the Aging Research program (CFDA 93.866) to Mayo Clinic to investigate the role of adipose senescent cells in cognitive function and Alzheimer's disease progression. The 5-year award, effective August 15, 2024, will support research to determine if the aging- or obesity-driven accumulation of senescent cells in adipose tissue contributes to cognitive deficits and neurodegeneration, including Alzheimer's-related...
This Project Grant award, valued at $2,309,934 and awarded by the National Institute on Aging (CFDA 93.866 Aging Research), aims to elucidate the role of brain aromatase in the development of Alzheimer's disease (AD) and evaluate pulsed photobiomodulation (PBM) therapy as a novel approach to prevent and manage AD. The award will support research conducted by the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to: Examine whether downregulation or...
The National Institute on Aging awarded a $2,250,745 Project Grant (CFDA 93.866 - Aging Research) to Mayo Clinic Jacksonville, doing business as Scott Lynch MD, to conduct research on the role of apolipoprotein E (APOE) in meningeal lymphatic function and its impact on Alzheimer's disease pathophysiology. The research aims to uncover the effects of APOE4 expression on meningeal lymphatic drainage and immune cell interactions, and how this may contribute to neuroinflammation and amyloid-β...