Project Grant RF1AG088811

Award Date 9/1/24
Completion Date 8/31/27
Dollars Obligated $3.3M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
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This National Institute on Aging (NIA) Project Grant award under the Aging Research federal grant program (CFDA 93.866) provides $372,690 to the University of California, Berkeley to uncover the heterogeneous causal pathophysiology of Alzheimer's disease (AD). The project aims to develop novel statistical methods to analyze existing datasets and reveal optimal treatment windows and target populations for whom reducing amyloid-beta or tau levels is most likely to yield cognitive benefits. Key...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,251,070 to the University of California Irvine through July 2025. The grant supports research to develop new statistical methodologies for analyzing Alzheimer's disease data from longitudinal cohort studies. Key deliverables include methods for assessing prediction precision for recurrent event survival data using time-dependent ROC and C-index...
This Project Grant award of $431,750 from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research to investigate the interaction between biological sex and APOE genotype in modulating Alzheimer's disease (AD) risk. The research will leverage human induced pluripotent stem cell lines with various APOE genotypes and sex chromosome complements to examine how APOE and sex influence amyloid-beta processing, tau hyperphosphorylation, and transcriptional changes...
This $3,845,311 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the University of California, San Diego (UCSD). The award aims to use induced neurons (iNs) derived from mild cognitive impairment (MCI) patients to investigate the early determinants and pathogenesis of Alzheimer's disease (AD). The project will integrate polygenic risk scores for AD with multi-omic profiling of MCI patient-derived iNs to better understand the...
The National Institute on Aging (NIA) awarded a Project Grant (CFDA 93.866 - Aging Research) in the amount of $661,016 to the University of Southern California (USC) to develop a "Federated Deep Learning to Accelerate Alzheimer's Disease Research" project. The key products and services to be delivered include: Establishing an international "Federate AD" alliance to leverage innovative AI techniques and distributed computation to study Alzheimer's disease (AD) across large,...
This $5,274,018 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The J. David Gladstone Institutes will study the susceptibility and resistance to the detrimental effects of the Apolipoprotein E4 (APOE4) genetic risk factor for Alzheimer's disease. The research aims to characterize neurophysiological, behavioral, and neuropathological differences between new APOE4 mouse lines...
The National Institute on Aging (NIA) awarded a $762,636 Project Grant (CFDA 93.866 - Aging Research) to The Leland Stanford Junior University (Stanford University) to develop interpretable machine learning methods for analyzing the genetics of Alzheimer's disease (AD). The goal is to discover causal genetic variants that could lead to new AD therapies. The project will apply the methods to genetic data from approximately 500,000 samples, with findings validated through functional experiments,...
The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), has awarded a $2,112,826 cooperative agreement to the University of California, San Diego (UCSD) to advance a CRISPR-based therapeutic for Alzheimer's disease (AD) towards pre-IND stage. The project aims to determine the optimal gene-editing combination to edit the APP gene, which plays a central role in AD pathogenesis, and shift the APP cleavage pathway from pathologic to physiologic. UCSD will evaluate...
The National Institutes of Health's National Institute on Aging awarded a $7,432,562 project grant to the Regents of the University of California, San Francisco on September 15, 2022 under the Aging Research program (CFDA 93.866). The grant will support research to elucidate the roles of Alzheimer's disease risk genes and variants in gene expression and AD-related phenotypes through 2025. Specifically, the University of California, San Francisco will use CRISPR and single-cell RNA sequencing...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $804,450 provides funding to the J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, to investigate the mechanisms behind selective neuronal dysfunction caused by the Alzheimer's disease genetic risk factor ApoE4. The research aims to 1) validate the protective effects of the protein NELL2 in hippocampal excitatory neurons of ApoE4 mouse models,...

The National Institute on Aging (NIA) awarded a $3,281,385 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of California, San Diego (UCSD) to leverage 30 years of Alzheimer's disease clinical trials data. The goal is to examine the role of specific patient phenotypes, such as sex/gender, APOE4 status, and polygenic hazard scores, on response to drug or lifestyle interventions. The project will analyze data from 14,602 participants across multiple Alzheimer's clinical trials, with plans to expand the dataset as new trials are completed. Statistical models will assess how these phenotypes interact with treatment on cognitive, functional, and biomarker outcomes. All derived data will be openly shared as a new resource for the scientific community. This effort aims to advance precision medicine approaches for understanding Alzheimer's risk factors and treatment responses.

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