The $433,824 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research program) supports research into transcriptomic control of dentate granule cell maturation and hyperexcitability in the APOE4 Alzheimer's disease model. The J. David Gladstone Institutes, a non-profit biomedical research organization in San Francisco, will conduct electrophysiological, transcriptomic, and morphological analyses of adult-born dentate granule cells to understand how APOE4...
This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, provides $4,563,558 under the Aging Research program (CFDA 93.866) to the Jackson Laboratory from September 15, 2022 to August 31, 2025. The funding supports research to model the genetic interaction between the Klotho and ApoE alleles in Alzheimer's disease. Specifically, the awardee will characterize new mouse models harboring relevant human variants in both Klotho and ApoE to...
This $1,170,000 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support a comprehensive study by Brown University to advance Alzheimer's disease treatment. The researchers aim to elucidate how the enhancer RNA "AANCR" regulates the APOE gene, a major genetic risk factor for Alzheimer's. Leveraging their expertise in RNA, genetics, and neurobiology, the team will investigate APOE expression regulation and function, including its...
The National Institute on Aging (NIA) has awarded a $919,106 Project Grant under the Aging Research (CFDA 93.866) program to the Sanford Burnham Prebys Medical Discovery Institute (SBP) in La Jolla, CA. The 5-year grant, spanning August 2024 to July 2029, supports research to discover and optimize "APOE4 correctors" - small molecules that can modulate the activity of the APOE4 protein, which is the strongest genetic risk factor for Alzheimer's disease. Specifically, the project aims to...
The National Institute on Aging (NIA) awarded a $341,000 Project Grant (CFDA 93.866 - Aging Research) to The Roskamp Institute, Inc., a non-profit research organization in Sarasota, Florida. The grant supports research to investigate the impact of the APOE4 genotype, a major genetic risk factor for Alzheimer's disease, on brain bioenergetics and metabolism. The goal is to examine how the GLP-1R-AMPK-ACC pathway in cerebrovascular cells and astrocytes is affected in APOE4 carriers, and whether...
This federal Project Grant awarded by the National Institute on Aging under CFDA 93.866 (Aging Research) aims to examine the role of specific phenotypes, such as sex/gender, APOE4 status, and polygenic hazard scores, on response to drug or lifestyle interventions in existing Alzheimer's disease clinical trials datasets. The $3,281,385 grant, awarded on September 1, 2024, will leverage data from 14,602 participants in 30 years of Alzheimer's clinical trials to analyze the impact of these...
The National Institute on Aging (NIA) awarded Emory University a $564,530 Project Grant (CFDA 93.866 - Aging Research) to investigate the associative role of the Alzheimer's disease risk gene APOE4 and the menopause-related hormone follicle-stimulating hormone (FSH) in the initiation and progression of Alzheimer's disease, particularly related to gender differences. The project aims to explore how APOE4 may facilitate Alzheimer's pathology in women through FSH-induced mechanisms, including...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will provide $431,750 to Arizona State University for a 2-year research project to dissect the interaction between biological sex and APOE genotype in modulating Alzheimer's disease (AD) risk. The key objectives are to: Use gene editing technology to introduce various APOE genotypes into induced pluripotent stem cell lines with different sex chromosome complements. Employ these cell...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) in the amount of $748,641 provides funding for research to characterize the structural changes and aggregation of amyloid protein and apolipoprotein E during the pathogenesis of Alzheimer's disease. The research team at The Washington University will utilize mass spectrometry-based protein footprinting techniques, including hydrogen/deuterium exchange and fast photochemical oxidation, to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) to The Roskamp Institute, Inc. in Sarasota, Florida provides $449,460 in funding to support research investigating the role of cerebrovascular dysfunction and bioenergetic deficits in the increased Alzheimer's disease risk associated with the APOE4 genetic variant. The research aims to determine how APOE4 disrupts L-carnitine-mediated bioenergetic pathways in brain endothelial and mural cells, and...